Nanovir LLC

Monsanto Company

University of Missouri

Other

Flexsys America L.p.

Washington University

Crosslink Polymer Research, a Division of Lumimove, Inc.

Kinlen, Patrick J.

Bashkin, James K.

James K Bashkin

Christopher Eugene Fisher

Kevin J Koeller

Terri Grace Edwards

Michael K Stern

Patrick John Kinlen

George D Harris, Jr

Yiwei Ding

Roger Keranen Rains

Anil S Modak

Shifeng Hou

James M Allman

Justice E Obi

George D Harris

The present invention relates to polyamide compounds and their use in pharmaceutical compositions and in medical applications for the treatment of human papillomavirus infections and/or polyomavirus infections.

Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses

Compositions and methods for the treatment of Bowen's disease, an orphan disease, are described. In addition, compositions and methods for the treatment of recurrent respiratory papillomatosis (RRP), an orphan disease, are described. Compositions and methods for the treatment of stage 1 melanoma are also described. The compositions comprise one or more active ingredients selected from the group consisting of: chloroquine, amodiaquine, and an antibiotic such as metronidazole. The methods comprise administering a therapeutically effective amount of such compositions to a subject in need thereof.

Compositions and methods for treatment of Bowen's disease and related diseases

The present invention relates to polyamide compositions and therapies for treating cells infected with papilloma virus (PV).

Methods for treating papilloma virus infection

The present invention relates to polyamide compositions and therapies for treating cells and subjects infected with papilloma virus.

Compounds for treating papilloma virus infection

Polyamide compositions containing guanidinyl radicals, including tetramethylguanidinyl radicals, are described. These polyamides are useful for medical applications, for example, for treating human papilloma virus infections.

Guanidinyl-substituted polyamides useful for treating human papilloma virus

The present invention relates to polyamide compositions and therapies for treating cells infected with papilloma virus.

Polyamides containing amino butyric acid-based building blocks

A method is provided for decontaminating a surface that is susceptible to contamination by a contaminant by applying to the surface a coating which produces a decontaminating agent for the contaminant in response to a signal, connecting the electroactive coating to a source of a signal, and when the surface is contaminated, applying the signal to the electroactive coating, thereby producing one or more decontaminating agents which neutralize or destroy the contaminant. Coatings for practicing the method and articles that have been protected by the novel coatings are also provided.

Signal activated decontaminating coating

The present invention relates to polyamide compositions and therapies for treating cells infected with human papilloma virus (HPV).

Polyamides for treating human papilloma virus

The selected sequence-directed hydrolysis of RNA under physiologically relevant conditions is described using conjugates comprising metal complexes covalently linked to oligodeoxynucleotides as hydrolysis agents. The oligodeoxynucleotide portions of the agents are selected to provide molecular recognition via the Watson Crick base pairing to the target RNA sequence to be hydrolyzed. A method is described for determining the RNA hydrolysis effectiveness of metals and ligands used to form the metal complexes useful in this invention.

RNA hydrolysis

A method of producing 4-ADPA is disclosed wherein aniline or substituted aniline derivatives and nitrobenzene are reacted under suitable conditions to produce 4-nitrodiphenylamine or substituted derivatives thereof and/or 4-nitrosodiphenylamine or substituted derivatives thereof and/or their salts, either or both of which are subsequently reduced to produce 4-ADPA or substituted derivatives thereof. The 4-ADPA or substituted derivatives thereof can be reductively alkylated to produce p-phenylenediamine products or substituted derivatives thereof which are useful as antiozonants. A second embodiment of the invention is the tetrasubstituted ammonium salts or alkyl substituted diammonium salts of 4-nitrodiphenylamine, 4-nitrosodiphenylamine and the substituted derivatives thereof wherein each substituent of the tetrasubstituted ammonium ion is independently selected from the group consisting of alkyl, aryl and arylalkyl groups and each alkyl substituent of the alkyl substituted diammonium salt is independently selected.

Method of preparing 4-aminodiphenylamine

A process for preparing p-nitroaromatic amides is provided which comprises contacting an amide and nitrobenzene in the presence of a suitable solvent system, and reacting the amide and nitrobenzene in the presence of a suitable base and a controlled amount of protic material at a suitable temperature in a confined reaction zone. The p-nitroaromatic amides of the invention can be reduced to p-aminoaromatic amides. In one embodiment, the p-aminoaromatic amide is further reacted with ammonia under conditions which produce the corresponding p-aminoaromatic amine and the amide starting material which can be recycled or with water in the presence of a suitable basic or acidic catalyst under conditions which produce the corresponding p-aminoaromatic amine and the acid or salt thereof corresponding to the amide starting material. In another embodiment, the p-aminoaromatic amine is reductively alkylated to produce alkylated p-aminoaromatic amine. The p-nitroaromatic amide can be reacted with ammonia under conditions which produce the corresponding p-nitroaromatic amine and the amide starting material which can be recycled or with water in the presence of a suitable basic or acidic catalyst under conditions which produce the corresponding p-nitroaromatic amine and the acid or salt thereof corresponding to the amide starting material. In one embodiment, the p-nitroaromatic amine is reduced to produce p-aminoaromatic amine. In another embodiment, the p-aminoaromatic amine is reductively alkylated to produce alkylated p-aminoaromatic amine. In another embodiment, the p-nitroaromatic amine is reductively alkylated to produce p-aminoaromatic amine.

Process for preparing p-nitroaromatic amides and products thereof

A method of producing 4-ADPA is disclosed wherein aniline and nitrobenzene are reacted under suitable conditions to produce 4-nitrodiphenylamine and/or 4-nitrosodiphenylamine and/or their salts, either or both of which are subsequently reduced to produce 4-ADPA. The 4-ADPA can be reductively alkylated to produce p-phenylenediamine products which are useful as antiozonants.

Growing community of inventors

St. Louis, MO, United States of America

James K Bashkin