Johnson Matthey Public Limited Company

Galleon Pharmaceuticals, Inc.

Rhodia Chirex, Inc.

Neurad Ltd.

James Joseph Mencel

Saroop Matharu

Xiaoyong Sun

Gurijala Venu Reddy

Scott L Dax

Edgars Suna

Jen-Sen Dung

Vita Ozola

Erno M Keskeny

Kirill Shubin

Carl Henry Behrens

Marina Martjuga

Paul Loren Fishbein

The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.

Breathing control modulating compounds, and methods of making and using same

Different polymorphs of bromfenac sodium may be prepared and interconverted using crystallization/recrystallization, drying and/or hydration techniques.

Methods for making polymorphs of bromfenac sodium and bromfenac sodium formulations

The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.

Breathing control modulating compounds, and methods of using same

Polymorphs of bromfenac sodium and methods for preparing bromfenac sodium polymorphs

A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol. This triol is substantially inert with respect to reforming 14-hydroxycodeinone and can be readily separated from oxycodone.

Low ABUK oxycodone, its salts and methods of making same

Improved analgesic oxymorphone hydrochloride contains less than 10 ppm of alpha, beta unsaturated ketones and pharmaceutical preparations comprising such oxymorphone hydrochloride. The oxymorphone hydrochloride is produced by reducing a starting material oxymorphone hydrochloride using gaseous hydrogen and under specified acidity, solvent system and temperature conditions. A specific polymorph of oxymorphone hydrochloride may be obtained by hydration.

Method for making analgesics

A process for making a water-soluble &#x3b2;-hydroxynitrile. A 1,2-epoxide and an inorganic cyanide salt are reacted in a solvent having aqueous methanol and a buffer therein to form &#x3b2;-hydroxynitrile. The buffer substantially inhibits the formation of reaction products other than &#x3b2;-hydroxynitrile. Optionally, water may be removed from the &#x3b2;-hydroxynitrile by azeotropic distillation with acetonitrile and subsequently purified via vacuum distillation and filtration.

Manufacture of water-soluble &#x3b2;-hydroxynitriles

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North Wales, PA, United States of America

James Joseph Mencel