Codexis, Inc.

Cargill Inc.

Shire Canada Inc.

James Joseph LaLonde

Gjalt W Huisman

Emily Mundorff

Jack S Liang

Rama Voladri

Stephan Jenne

Lisa Marie Newman

Jian Ding

Stephane J Jenne

Lorraine Joan Giver

John M Gruber

Behnaz Behrouzian

John H Grate

John D Munger, Jr

Jun Zhu

Xiyun Zhang

Derek J Smith

Fabien Louis Cabirol

Benjamin Mijts

Anupam Gohel

Michael D Clay

Jagadeesh Mavinahalli

Seong Ho Oh

Roger Arthur Sheldon

Sheela Muley

Brian Wong

Jeffrey Colbeck

Vesna Mitchell

Birthe Borup

Dean Brady

Alex Cimpoia

Subash Buddoo

Amanda Louise Rousseau

Yiming Yao

Yifong Wang

Fabien Cabirol

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane

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The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3'-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate

The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor

Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

Engineered ketoreductases and methods for producing stereoisomerically pure statins

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M', and Rare as described herein.

Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

Growing community of inventors

Palo Alto, CA, United States of America

James Joseph LaLonde