Fusion Antibodies Limited

The Queen's University of Belfast

James Johnston

Christopher Scott

Shane Olwill

Richard John Buick

Roberta Burden

Julie Gormley

Jaquin Thomas

Darragh McMeel

Shaun Spence

Danny McAuley

Francois Fay

Jill Caswell

Thomas Jaquin

Declan Doherty

Hangfai Kwok

Danny Mcauley

The invention relates to a method of inhibiting chemotherapy induced upregulation of Cathepsin S on the surface of tumor cells, the method comprising the administration of a Cathepsin S inhibitor to said cells. Also provided is a therapy comprising an anti Cathepsin S antibody, in particular an anti-Cathepsin S antibody which does not inhibit the proteolytic effect of Cathepsin S but nevertheless inhibits angiogenesis and a combination treatment comprising a Cathepsin S inhibitor and a therapeutic agent.

Therapy targeting cathepsin S

There is provided a method for suppressing a pro-inflammatory immune response in a cell, comprising providing to a cell sialic acid or analogs thereof, wherein the sialic acid or analogs are presented by a substrate such that a pro-inflammatory immune response in a cell is suppressed or an anti-inflammatory immune response is increased in a cell. Further, there is provided a method of treatment of inflammatory disease in a subject in need thereof. There is also provided a drug delivery device and a biomaterial which can modulate the inflammatory response in a subject.

Modulator

Described are cross-specific antibody molecules with binding specificity for both AREG and HBEGF. The antibody molecules may be used in methods of treatment of cancer and diseases associated with angiogenesis.

Anti-AREG/HB-EGF antibodies and treatment

The invention relates to the identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis and the discrimination between infected animals and animals previously exposed to vaccines.

Assays for diagnosis of tuberculosis and uses thereof

Growing community of inventors

Belfast, United Kingdom

James Johnston