Biochain Institute, Inc.

Biochain (Beijing) Science & Technology, Inc.

James Jianming Wang

Xiaoliang Han

Tong Lu

Yongzhan Nie

Daiming Fan

Kaichun Wu

The present invention provides a composition, a kit and the use thereof, as well as the method for detecting the cell proliferative abnormality in individuals or grading the disease degree in the individuals. The composition comprises nucleic acids for detecting the methylation level within at least one target region of a gene and the fragment thereof.

Gene composition for detecting cell proliferative abnormality or grading disease degree and use thereof

The present teachings relate to methods, kits and devices for performing automated sequential nucleic acid isolation and conversion/purification in a single closed system. In various embodiments, the present teaching enable a user to (i) load a device with test samples, reagents and consumables; (ii) select or program the device for the desired nucleic acid isolation and subsequent chemical treatment and/or conversion reaction(s) without further user intervention; and recovering the isolated and treated and/or converted nucleic acid at the conclusion of the program once the device is activated.

Automated isolation and chemical reaction(s) of nucleic acids

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Newark, CA, United States of America

James Jianming Wang