Thorlabs Gmbh

Praevium Research, Inc.

Leland Stanford Junior University

James Jiang

Alex Cable

Vijaysekhar Jayaraman

Benjamin Michael Potsaid

Scott Barry

Jeffrey S Brooker

Dierck Hillmann

Jörn Wollenzin

Kirk Gossage

Jason Matthew Mills

Ross Johnstone

Steven Chu

Yilei Li

Noah Yuzo Toyonaga

Anjul M Davis Loiacono

Marshall Scott

Eric Geoffrion

Benjamin Postsaid

Jorn Wollenzin

Jason Mills

Beniamin Potsaid

This disclosure relates to combined frequency and angle compounding for speckle reduction in ultrasound imaging. Such combined frequency and angle compounding can result in a multiplicative speckle reduction compared to using either frequency compounding or angle compounding alone. Compounding methods of this disclosure can make use of the full aperture of the ultrasound probe when acquiring individual images, hence there can be no compromise in resolution. In disclosed embodiments, ultrasound images can be obtained while an ultrasound probe is moving and the relative position and orientation of the ultrasound images can be determined from a measurement of the position and orientation of the ultrasound probe. Certain embodiments can correct for the movement and distortion of an object being imaged during the image acquisition.

Combined frequency and angle compounding for speckle reduction in ultrasound imaging

Disclosed is an optical probe system that is capable of high speed, high precision, and high resolution 3D digitalization of engineered objects. The 3D dimensional data of the engineered object is measured using a swept source optical coherence tomography system with improved speed, spatial resolutions, and depth range. Also disclosed is a type of coordinate measurement machine (CMM) that is capable of performing high speed, high resolution, and non-contact measurement of engineered objects. The mechanic stylus in the touch-trigger probe of a conventional CMM is replaced with an optical stylus with reconfigurable diameter and length. The distance from the center of the optical stylus to the measurement probe is optically adjusted to match the height of the object to be measured quickly, which eliminates one dimensional movement of the probe and greatly improves the productivity.

MEMS tunable VCSEL powered swept source OCT for 3D metrology applications

An agile optical imaging system for optical coherence tomography imaging using a tunable source comprising a wavelength tunable VCL laser is disclosed. The tunable source has long coherence length and is capable of high sweep repetition rate, as well as changing the sweep trajectory, sweep speed, sweep repetition rate, sweep linearity, and emission wavelength range on the fly to support multiple modes of OCT imaging. The imaging system also offers new enhanced dynamic range imaging capability for accommodating bright reflections. Multiscale imaging capability allows measurement over orders of magnitude dimensional scales. The imaging system and methods for generating the waveforms to drive the tunable laser in flexible and agile modes of operation are also described.

Agile imaging system

An optical instrument including at least a first and second wavelength swept vertical cavity laser (VCL) sources. The wavelength sweeping ranges spanned by the first and second VCL sources may differ with a region of spectral overlap. The first and second VCL sources may be operable under different modes of operation, wherein the modes of operation differ in at least one of: sweep repetition rate, sweep wavelength range, sweep center wavelength, and sweep trajectory. A VCL source may also exhibit sweep-to-sweep variation. Apparatus and methods are described for aligning sample signal data from the first VCL and sample signal data from the second VCL to generate output digital data. The output digital data is aligned with respect to at least one of: wavelength, wavenumber, and interferometric phase. The apparatus and methods can also be used to phase stabilize successive sweeps from the same VCL source or wavelength swept source.

Apparatus and methods for one or more wavelength swept lasers and the detection of signals thereof

A system capable of highly sensitive measurement of material concentration values in a sample using an optical spectroscopic method is disclosed. The system utilizes high-speed data acquisition and high resolution sampling of the raw signals output by the sensors with reduced total channel counts, and performs frequency analysis of the signals using the Fourier transform method to process all sensor channels in parallel. When each sensor is targeting the detection of some certain materials at some certain frequencies, the system is capable of simultaneous detection of multiple materials of interest in the sample with high measurement sensitivity and high speed.

Optical spectroscopic measurement system

Disclosed are several technical approaches of using low coherence interferometry techniques to create an autofocus apparatus for optical microscopy. These approaches allow automatic focusing on thin structures that are positioned closely to reflective surfaces and behind refractive material like a cover slip, and automated adjustment of focus position into the sample region without disturbance from reflection off adjacent surfaces. The measurement offset induced by refraction of material that covers the sample is compensated for. Proposed are techniques of an instrument that allows the automatic interchange of imaging objectives in a low coherence interferometry autofocus system, which is of major interest in combination with TDI (time delay integration) imaging, confocal and two-photon fluorescence microscopy.

Microscopy system with auto-focus adjustment by low-coherence interferometry

An optical imaging system includes an optical radiation source (), a frequency clock module outputting frequency clock signals (), an optical interferometer (), a data acquisition (DAQ) device () triggered by the frequency clock signals, and a computer () to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source () to externally clock the sampling process of the DAQ device (). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further includes multiple stages of routers () connecting the light source () with a plurality of interferometers (a-n) and a DAQ system () externally clocked by frequency clock signals to perform high-speed multi-channel optical imaging of samples.

Optical coherence tomography imaging system and method

An optical imaging system includes an optical radiation source, a frequency clock module outputting frequency clock signals, an optical interferometer, a data acquisition (DAQ) device triggered by the frequency clock signals, and a computer to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source to externally clock the sampling process of the DAQ device. The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further includes multiple stages of routers connecting the light source with a plurality of interferometers and a DAQ system externally clocked by frequency clock signals to perform high-speed multi-channel optical imaging of samples.

An optical imaging system includes an optical radiation source (), a frequency clock module outputting frequency clock signals (), an optical interferometer (), a data acquisition (DAQ) device () triggered by the frequency clock signals, and a computer () to perform multi-dimensional optical imaging of the samples. The frequency clock signals are processed by software or hardware to produce a record containing frequency-time relationship of the optical radiation source () to trigger the sampling process of the DAQ device (). The system may employ over-sampling and various digital signal processing methods to improve image quality. The system further includes multiple stages of routers () connecting the light source () with a plurality of interferometers (-) and a DAQ system () triggered by frequency clock signals to perform high-speed multi-channel optical imaging of samples.

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Hackettstown, NJ, United States of America

James Jiang