Wyeth

James Jacob Bicksler

Wayne Everett Childers

Lisa Marie Havran

Albert Jean Robichaud

Boyd Lynn Harrison

Annmarie Louise Sabb

Donna Mary Huryn

Paul Jeffrey Dollings

Alexander Greenfield

Magda Asselin

George Theodore Grosu

Arlene J Dietrich

Zhongqi Shen

Dan Chaekoo Chong

Chae-Koo Dan Chong

Vasilios Marathias

The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction. The invention relates to compounds and pharmaceutically acceptable salts of formula (I'): wherein R-R, R, R, and n are set forth in the specification. The invention also relates to pharmaceutical compositions comprising compounds and pharmaceutically acceptable salts of formula (I&#x2032;).

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Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis and apoptosis are also disclosed.

Pyrimidoindolones and methods for using same

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Titusville, NJ, United States of America

James Jacob Bicksler