Emd Millipore Corporation

Millipore Corporation

James J Vigna

Joseph William Muldoon

Robert Ezra Langlois

James E Kelly

John Cieciuch

Jean-Louis Weissenbach

Stephen Proulx

Rene Reinbigler

Martin Morrissey

Ralph J Stankowski

Cecile Delbos

Wayne S Merrill

Joseph M Almasian

Brian Pereira

Stephen G Hunt

Boris Pesakovich

Joseph Cianciolo

Paul Lowell

Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

Sterile connection/disconnection coupling and method

The present invention is a disposable bioreactor formed of molded plastic. The bioreactor is presterilized and has a top and body sealed to each other. One or more ports are formed in the top and side of the housing. Preferably at least one port is below the liquid/air level for the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports or access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment location is also guaranteed through the use of the molded port features. The molded plastic allows for greater flexibility in material selection to reduce or eliminate lipid or cholesterol binding.

Stirred tank bioreactor

A device for determining a physical value of a liquid flowing in a pipe, without contact with said liquid, said device comprising:

Device for determining a physical value of a liquid flowing in a pipe

A connector is provided for connecting a flexible conduit with a second conduit having a barbed outer surface. The connector accommodates the end of the flexible conduit and the end of the second conduit in a manner which prevents removal of the flexible conduit and the second conduit from the connector. Optionally, the connector has a ring that may be used to apply additional pressure and security to the outer surface of the flexible conduit. additionally, the connector may have a wireless enabled communication and optionally, memory device such as a RFID tag attached or affixed to it.

Connector for flexible tubing

A device for determining a physical value of a liquid flowing in a pipe, without contact with the liquid. The device includes: a sensor for the physical value; a connector to insert into the pipe and including: an internal passage extending between two apertures, a flexible membrane for a pressure sensor, forming a wall of the internal passage; and a fastening mechanism for fastening the sensor onto the connector. The sensor is a temperature sensor fastened to the connector with the sensitive part of the sensor turned towards the membrane.

A method is disclosed for making a substantially flat filter plate comprising a substantially flat polymer, preferably thermoplastic, frame and substantially flat filter material seated fixedly therein. The method is characterized by its reduced exposure of the filter material to adverse mechanical stresses resultant of polymeric frame formation and curing. Toward such end, the substantially flat polymeric frame is formed in at least two separate steps, in the course of which said substantially flat filter material is incorporated. The portion formed first serves as a mechanical restraint, insulating the later incorporated filter material from any propensity of the second 'embedding' portion to shrink or otherwise warp during its formation.

Method for the manufacture of a composite filter plate

A fluid path control element which when stacked alternatively with a fluid porous sheet can be formed into a filtration module. The fluid path control element comprises a porous membrane having sealed to a portion of its periphery a thermoplastic element that extends into an opening either through the membrane or in an opening through the thermoplastic element. The portion of the thermoplastic element that extends into the opening can be heat sealed with a second thermoplastic element to prevent fluid flow between the opening and the membrane.

Fluid path control element for fluid processing module

A method is disclosed for making a substantially flat filter plate comprising a substantially flat thermoplastic polymer frame and substantially flat filter material seated fixedly therein. The method is characterized by its reduced exposure of the filter material to adverse mechanical stresses resultant of thermoplastic frame formation and curing. Toward such end, the substantially flat thermoplastic frame is formed in at least two separate steps, in the course of which said substantially flat filter material is incorporated. The portion formed first serves as a mechanical restraint, insulating the later incorporated filter material from any propensity of the second 'embedding' portion to shrink or otherwise warp during its formation.

A process for making a fluid processing module is provided wherein a plurality of filtration elements is alternated with a fluid porous layer to form a stack. The filtration elements comprise a membrane sheet having a thermoplastic element bonded to a portion of an edge of the membrane. An opening is provided either through the membrane or through the thermoplastic element. A portion of the thermoplastic element extends into the opening and can be sealed to an adjacent positioned thermoplastic element to seal the porous sheet positioned between adjacently positioned membranes from fluid communication with the opening. Sealing can be effected by extending a heating element through the opening of the stack to effect simultaneous sealing of a plurality of thermoplastic elements.

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Billerica, MA, United States of America

James J Vigna