Eli Lilly and Company

Eastern Virginia Medical Authority

James J Starling

Mark Alan Winter

Anne H Dantzig

Robert L Shepard

Srinivasan Chandrasekhar

Jason Scott Sawyer

Stephen M Spaethe

George L Wright, Jr

The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

Methods for treating resistant tumors

Methods for reversing multidrug resistance

This invention provides a method of reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of a series of phenoxy compounds as defined herein.

Method for treating resistant tumors

Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens but not to prostate-specific antigen (PSA) or prostatic acid phosphatase (PAP); and methods of diagnosis and treatment employing the same.

Monoclonal antibodies having binding specificity to human prostate

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Carmel, IN, United States of America

James J Starling