Axelgaard Manufacturing Company, Ltd.

Kimberly-clark Worldwide, Inc.

Ballard Medical Products, Inc.

Cardiotronics Systems, Inc.

James J Perrault

Jens Axelgaard

Edward B Madsen

Steve Heard

Cameron G Rouns

L John Teuscher

Solomon E Shenkute

George S Heard

Solomon E Shentuke

Tim J Way

Jeffrey Alan Bennett

An electrode providing electrical contact with a patient's skin includes a conductive member adapted for connection to an external electrical apparatus and a non-liquid water containing film for electrically interfacing to said patient's skin, the non-liquid film being electrically and mechanically connected to said conductive member. The non-liquid water containing film includes an electrically conductive organic polymer plasticized with a polyhydric alcohol with said organic polymer being derived from a monomeric mixture comprising from about 2 to 30 pph acrylic acid, 2 to 30 pph of a glycolvinylether and 0.01 to 1.5 pph of a crosslinking agent. Preferably the polyhydric alcohol is glycerol.

Method for making a medical electrode polymer

An electrode providing electrical contact with a patient's skin includes a conductive member adapted for connection to an external electrical apparatus and a non-liquid film for electrically interfacing to said patient's skin, the liquid film being electrically and mechanically connected to said conductive member. The non-liquid film includes an electrically conductive organic polymer plasticized with a polyhydric alcohol with said organic polymer being derived from a monomeric mixture comprising from about 15 to 30 pph acrylic acid, 0.5 to 30 pph N-vinylpyrrolidone and 0.01 to 2 pph of a crosslinking agent. The monomeric mixture may further comprise from about 0.5 to 8 pph of a thickening agent selected from the group consisting of N-vinylpyrrolidone/acrylic acid copolymers, N-vinylpyrrolidone/vinylacetate copolymers, and N-vinylpyrrolidone/vinylimidazole copolymers.

Medical electrode

Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is first subjected to a solvent and a multi-functional monomer. The solvent causes the multi-functional monomer to become imbibed into the surface of the medical device. Thereafter, a polymer having lubricious properties is polymerized on the surface of the device. The multi-functional monomer reacts with the polymer coating securely affixing the polymer coating to the device.

Lubricious coating for medical devices

A composition and method for treating a wound with an inherently antimicrobial dressing. The dressing is a hydrogel containing from about 15 to 95 percent, and preferably from about 61 to 90 percent, by weight of a cationic quaternary amine acrylate polymer prepared by the polymerization of acryloyloxyethyl(or propyl)-trialkyl(or aryl)-substituted ammonium salts or acrylamidoethyl(or propyl)-trialkyl(or aryl)-substituted ammonium salts. The antimicrobial hydrogels are non-irritating to the wound, absorb wound exudate, and, due to the inherently antimicrobial properties, enhance the sterile environment around the wound. The hydrogels have sufficient adhesive properties that loose contact with the wound is assured but can also be removed without leaving any gel residue on the wound. The wound dressings are preferably formed on a substrate, such as a web or patch, for ease in application to and removal from the wound. If desired, additional antimicrobial or other pharmaceutically active agents can also be incorporated into the hydrogel structure.

Inherently antimicrobial quaternary amine hydrogel wound dressings

A dermal fastener includes a first adhesive for adherence to an article and a second adhesive for adherence to skin. The second adhesive is a non-liquid water containing film including an organic polymer plasticized with a polyhydric alcohol with the organic polymer being derived from a monomeric mixture including from about 2 to about 30 pph acrylic acid to about 1 to about 30 pph of a glycolvinylether and about 0.01 to about 1.5 pph of a crosslinking agent. The first and second adhesives may also be disposed on opposite sides of a membrane if partition of fluid components in the adhesives is desired.

Dermal fastener

Electrotransport adhesive for iontophoresis device

A composition providing electrically conductive adhesive hydrogels suitable for use as skin contact adhesives and, particularly, suitable for use as an electrical interface for disposable medical devices. The hydrogels are cationic acrylates and may be, for example, preferably made from acrylic esters of quaternary chlorides and/or sulfates or acrylic amides of quaternary chlorides. The present hydrogels are formed by free radical polymerization in the presence of water, preferably by ultra-violet curing with initiator and multi-functional cross-linking agent. The present hydrogels also preferably include a buffer system to help prevent discoloration of the hydrogels and/or hydrolysis of the hydrogels and/or improve shelf-life. Other additives may be added to the present hydrogels either before or after curing (i.e. conductivity enhancers, pharmaceuticals, humectants, plasticizers, etc.) depending on intended end-use. The present hydrogels hydrate a subject's skin, readily wet around a subject's skin surface hair (e.g. chest hair), and protect against burning of a subject upon or due to electrical stimulation through the hydrogel. In addition, the present hydrogels are sufficiently cohesive to enable direct hydrogel-to-hydrogel contact and storage (i.e. without a barrier therebetween), yet remain readily separable. Furthermore, the present hydrogels may be presented in a formula which is non-corrosive to aluminum in contact therewith, and pass standards testing for biocompatibility and electrical properties as developed by the Association for the Advancement of Medical Instrumentation (AAMI) and accepted by the American National Standards Institute.

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Vista, CA, United States of America

James J Perrault