H. Lee Moffitt Cancer Center and Research Institute, Inc.

University of Michigan

Board Nf Regents the Inivercitvof Texas Cvctom

The University of Texas System

James J Mulé

Timothy J Yeatman

Michael V Nebozhyn

Domenico Coppola

Andrey Loboda

Shari Pilon-Thomas

Amod A Sarnaik

Anthony M Magliocco

Jeffrey S Weber

Laszlo G Radvanyi

Jessica Ann Chacon

Audrey Loboda

MacLean S Hall

Anders Erik Berglund

Norimasa Matsushita

Annabelle Grolleau-Julius

Disclosed herein is a method for ex vivo expanding tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). The method involves culturing tumor fragments from the subject in a culture medium containing IL-2 and a 41BB agonist in an amount effective to expand tumor-infiltrating lymphocytes with enriched tumor-reactivity and specificity. Also disclosed is a method for treating a tumor in a subject that involves treating the subject with nonmyeloablative lymphodepleting chemotherapy, and administering tumor-infiltrating lymphocytes expanded by the disclosed methods.

Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy

This invention relates to methods for treating subjects with breast cancer, based on tumor expression levels of chemokines.

Immune gene signatures in treating breast cancer

This invention relates to methods for treating subjects with bladder cancer, such as urothelial carcinoma, based on mRNA expression levels of chemokines.

Immune gene signatures in urothelial carcinoma (UC)

This invention relates to methods for selecting a treatment, treating, and predicting survival time in subjects with cancer, such as colorectal cancer, based on tumor expression levels of chemokines, cytotoxic genes, and/or dendritic cell genes.

Immune gene signatures in cancer

The invention provides compositions and methods of treating various conditions, including tumors, with compositions comprising dendritic cells expressing exogenous chemokines.

Creating bioengineered lymph nodes

Described herein are methods of cancer immunotherapy, particularly methods of preparing a population of enhanced dendritic cells and methods of treating cancer using the enhanced dendritic cells.

Enhanced dendritic cells for cancer immunotherapy

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Odessa, FL, United States of America

James J Mulé