University of California

James J La Clair

Michael D Burkart

Reymundo Villa

Justin C Hammons

Alexander L Mandel

Brian D Jones

William H Fenical

Paul R Jensen

Lynnie Lin Trzoss

Takashi Fukuda

Catriona Jamieson

Leslie Crews Robertson

Sachin Dhar

Januario E Castro

Manoj Kumar Kashyap

Larisa Balaian

Deepak Kumar

MinJin Kang

Heather Leu

Wei-Luen Yu

Brian Leon

Nathaniel Delos Santos

Warren C Chan

Kelsey A Trieger

Catriona Hm Jamieson

Provided herein, inter alia, are splice modulator compounds. The compounds include optically pure, stereospecific analogs of FD-895. The methods provided herein allow, for example, for scalable preparation of said compounds, and further allow, for example, use of said compounds for inhibiting spliceosome activity.

Anticancer and antifungal splice modulators

There are provided inter alia stable anti-cancer compounds and splice modulators and methods of synthesis and use thereof.

Anti-cancer and splice modulating compounds and methods

There are provided, inter alia, methods and compositions for diagnosis and treatment of acute myeloid leukemia (AML), secondary acute myeloid leukemia (sAML), and age-related diseases.

Methods for detection and eradication of myeloid leukemia stem cells

Provided herein, inter alia, are anticancer polyketides. The uses of the polyketides described herein include treatment of cancer, for example, through regulation of the spliceosome and detection of spliceosome inhibition.

Anti-cancer polyketide compounds

There are provided, inter alia, derivatives of seriniquinone and methods useful for the treatment of cancer, and in particular treatment of melanoma and prostate cancer.

Seriniquinones, melanoma-specific anticancer agents

The present disclosure relates generally to compositions and methods for treating cancer. In some aspects, novel spirohexenolides and methods of using and producing them are described.

Anticancer agents

The invention relates to a device and a method for analyzing the interaction between one or more molecular species the method comprising the steps of creating streams of digital data, transferring the stream of digital data through a substrate, manipulating the molecular structure of the substrate by adding or subtracting molecules or groups of molecules to be examined to or from the substrate, receiving the streams of digital data transferred through the substrate, decoding the identity of an examined molecule or group of molecules interacting with the substrate by deciphering how the molecules affinity to another molecule or group of molecules or molecular sensor or group of molecular sensors alters the stream of digital data. The invention relates further to a method for identifying molecular species, and to a device for identifying molecular species and to a substrate for analyzing the interaction and for identifying molecular species.

Method and device for identifying molecular species

Growing community of inventors

San Diego, CA, United States of America

James J La Clair