Pfizer Corporation

James J Korst

Hermann Faubl

Timothy H Cronin

William W Hoffman

A process for inducing the production of endogenous interferon in a vertebrate animal which comprises parenterally, intranasally or topically adminstering to the animal an interferon-inducing effective amount of composition containing as the essential active ingredient a compound of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.7 and R.sub.8 are each alkyl of from 12 to 30 carbon atoms and Z is selected from the group consisting of N-(lower alkyl)-piperazino and N-(W-hydroxy-lower alkyl)-piperazino, said lower alkyl groups having from 1 to 4 carbon atoms.

Interferon induction in animals by amines

Combating viral infections in vertebrate animals by administering to the animals a monoamine, a diamine or a triamine.

Combating viral infections in vertebrate animals by administering to the animals an amine selected from those having the formulae: ##STR1## and the non-toxic acid addition salts thereof wherein R.sub.1 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms and ##STR2## R.sub.2 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms, aralkyl and aryloxyalkyl of from 12 to 24 carbon atoms and ##STR3## R.sup.o is alkoxy of from 1 to 18 carbon atoms; EACH OF R' and R' is selected from the group consisting of hydrogen, alkyl, alkoxy of from 1 to 18 carbon atoms; R' and R' when taken together are methylenedioxy;

Compounds of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.1 is alkyl of from 1 to 20 carbon atoms;

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Old Lyme, CT, United States of America

James J Korst