Schering Corporation

James J Kaminski

Daniel M Solomon

Steven K White

Ashit K Ganguly

Pauline C Ting

Wing C Tom

Nicholas I Carruthers

Shing-Chun C Wong

Laura S Lehman De Gaeta

David J Conn

Elijah H Gold

Margaret H Sherlock

Chester Puchalski

Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease.

Tricyclic derivatives, compositions and methods of use

Pentacyclic antihistamines

Novel 2,2-disubstituted glycerol-like compounds are disclosed for use as anti-allergic and anti-inflammatory compounds. The compounds are antagonists of platelet activating factor ('PAF'). Also disclosed are methods of synthesizing and using the compounds of the invention as well as pharmaceutical compositions thereof. The compounds have the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as defined in the specification.

2,2 disubstituted glycerol and glycerol-like compounds, compositions and

2,2-disubstituted glycerol and glycerol-like compounds, compositions and

Heterobicyclic compounds having antiinflammatory activity

Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H, 9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents. Methods for their preparation and use are described.

Substituted-2,3-dihydro-6-substituted-pyrimido[2,1-F]-purine-

Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H,9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents. Methods for their preparation and use are described.

Method of treating hyperploliferative skin disease with

Substituted 2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]purine-4,8(1H,9H)-diones their tautomers and salts, are anti-inflammatory and anti-allergy agents. Methods for their preparation and use are described.

Anti-inflammatory and anti-allergic

There are disclosed certain substituted tricyclic imidazo[1,2-a]pyridines which are useful in the treatment of peptic ulcer diseases.

Growing community of inventors

Long Valley, NJ, United States of America

James J Kaminski