American Cyanamid Company

Wyeth

James J Gibbons, Jr

Semiramis Ayral-Kaloustian

Mila T Du

Steven R Schow

Gary Dukart

Lisa Anne Speicher

Philip Frost

Sridhar Krishna Rabindran

Carolyn Mary Discafani-Marro

Judy Lucas

Jeremy Ian Levin

Joseph William Epstein

This invention provides the use of CCI-779 in the treatment of neoplasms.

Use of CCI-779 as an antineoplastic agent

This invention provides a method of treating solid tumors which comprises administering an effective amount of a combination of (1) a bioresponse modifier and (2) a chemotherapeutic agent. This invention also provides a method of potentiating the effects of a chemotherapeutic regimen in a mammal in need of treatment with such regimen which comprises administering a bioresponse modifier in addition to a chemotherapeutic regimen.

Method of potentiating chemotherapy and treating solid tumors

This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Treatment of neoplasms with CCI-779/EKB-569 combination

Antineoplastic combinations comprising

The invention is a method of treating or inhibiting neutropenia, or accelerating neutrophil recovery in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each, independently selected from the group consisting of hydrogen, alkyl of 1-6 carbon atoms, optionally substituted benzoyl, ##STR2## or R.sub.1 and R.sub.2 are methylene groups which are taken together to form a 4-7 membered saturated heterocyclic ring;

Method of treating or inhibiting neutropenia

The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

Urethanes and ureas that induce cytokine production

Urethanes and ureas that enhance the growth of bone marrow progenitor

Growing community of inventors

Westwood, NJ, United States of America

James J Gibbons, Jr