Abbott Laboratories Corporation

Wyeth

Abbvie Inc.

James J Fort

William Porter

Rodger F Henry

Sanjay R Chemburkar

Daniel A Dickman

David Lechuga-Ballesteros

Yuping Niu

Eric Allen Schmitt

Steven L Krill

Devalina Law

David Hugh Giamalva

Geraldine Doyle

Steven Cooper

Graham D Cook

Todd S Koch

Justin Bianco

Yihong Qiu

William R Porter

The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsule composition, to prevent interaction between the active ingredients.

Treatment of sleep disturbances

A pharmaceutical composition is disclosed which comprises a solid dispersion of a pharmaceutical compound in a water soluble carrier, such as polyethylene glycol (PEG), and a crystallization inhibitor, such as polyvinylpyrrolidone or hydroxypropylmethylcellulose. The solid dispersion may optionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treatment employing said solid dispersion.

Inhibitors of crystallization in a solid dispersion

New crystalline forms of lopinavir are disclosed.

Crystalline pharmaceutical

A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may optionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treating an HIV infection employing said solid dispersion.

Solid dispersion pharamaceutical formulations

The present invention is directed to a solid formulation comprising the lipid-regulating agent dispersed in a hydrophilic, amorphous polymer in which said lipid-regulating agent is present as a meta-stable, amorphous phase.

Formulations comprising lipid-regulating agents

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Midlothian, VA, United States of America

James J Fort