University of California

Lawrence Livermore National Security, LLC

James J De Yoreo

Ronald N Zuckermann

Julio A Camarero

Chun-Long Chen

Alexander R Mitchell

Youngeun Kwon

Sally J Marshall

Grayson W Marshall

Yung-Ching Chien

Kuniko Saeki

The present invention provides for a bio-mimetic polymer capable of catalyzing or mineralizing calcium ion and phosphate ions into an apatite.

Peptoids useful for the mineralization of apatite

The present invention provides for a bio-mimetic polymer capable of catalyzing COinto a carbonate.

Peptoids useful for catalyzing the mineralization of calcium carbonate

Described herein is a method for the attachment of proteins to any solid support with control over the orientation of the attachment. The method is extremely efficient, not requiring the previous purification of the protein to be attached, and can be activated by UV-light. Spatially addressable arrays of multiple protein components can be generated by using standard photolithographic techniques.

Photoswitchable method for the ordered attachment of proteins to surfaces

Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide &#x3b1; thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. When the peptide synthesis has been completed, activation of the linker is achieved by mild oxidation. The oxidation step converts the acyl-hydrazine group into a highly reactive acyl-diazene intermediate which reacts with an &#x3b1;-amino acid alkylthioester (H-AA-SR) to yield the corresponding peptide &#x3b1;-thioester in good yield. A variety of peptide thioesters, cyclic peptides and a fully functional Src homology 3 (SH3) protein domain have been successfully prepared.

Synthesis of peptide &#x3b1;-thioesters

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Clayton, CA, United States of America

James J De Yoreo