American Home Products Corporation

James J Bicksler

John H Musser

Anthony F Kreft, Iii

Dennis Michael Kubrak

John W Giberson

Annette L Banker

John W Ellingboe

Kenneth L Kees

Madelene Nikaido

Dimitri Sarantakis

Winifred P Howse

This invention relates to substituted 4-aminopyrimidines, which by virtue of their ability to antagonize angiotensin II are useful for the treatment of hypertension, congestive heart failure, and restenosis. The compounds are also useful for reducing lipid levels in the blood plasma and are thus useful for treating hyperlipidemia and hypercholesterolemia. Also disclosed are processes for the production of said compounds and pharmaceutical compositions containing said compounds.

Substituted aminopyrimidines as antihypertensives

There are disclosed compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl;

Quinolinylmethoxy naphthalenepropionic acid derivatives as

There are disclosed compounds of the formula ##STR1## wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, ##STR2## with the proviso that A is not quinolinyl; W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O--;

Naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic

There are disclosed compounds of the formula ##STR1## wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, ##STR2## W is --CR.sub.2 O--, --CH.dbd.CH-- or --CH.dbd.CHCH.sub.2 O-- X is N or CR;

Quinoline substituted naphthalenepropionic acid derivatives as

There are disclosed compounds of the formula ##STR1## wherein A is alkyl of 3-19 carbon atoms, diloweralkyl allyl, dihaloallyl, diphenylallyl, lower alkynyl, ##STR2## X is N or CR; Z is ##STR3## R is hydrogen or lower alkyl; R.sup.1 is hydrogen, lower alkyl or phenyl;

Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic

There are disclosed compounds having the formula ##STR1## wherein X is CR or N when n=1; or

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Cranbury, NJ, United States of America

James J Bicksler