Fine Organics Limited

Lonza Inc.

Glaxo Group Limited

Laporte Industries Limited

Agro-kanesho Co., Ltd.

Arthur Jackson

Paul Edward Rowney

Graham Heyes

James Ian Grayson

Paul E Rowney

James Orrock Macgregor

Brian John Somerville

Russell Clarke

A process for preparing a vinyl isothiocyanate comprises contacting a halogen-substituted allyl thiocyanate, in solution and at an elevated temperature, with an acidic material which is either an acid or a halide or oxyhalide of an inorganic acid. The halogen-substituted allyl thiocyanate may be prepared from a dihalogenated alkene. The vinyl isothiocyanate may subsequently be converted to a thiazole.

Preparation of vinyl isothiocyanates

A process for the preparation of a substituted thiazole comprises reacting an isothiocyanate compound of the general formula

Preparation of substituted thiazoles

Preparation of substituted ethenes

According to the invention, there is provided a process for the preparation of an aminoalkyl p-hydroxyphenyl ketone comprising reacting phenol with a nitrile, in the presence of a Lewis acid catalyst, to cause condensation thereof, the process being characterised in that the reaction is carried out in a medium comprising a nitroalkane solvent for the reactants.

Process for the preparation of ketones

A potassium salt useful in the production of N-substituted-1-alkylthio-2-nitroethenamines is produced by the reaction of the dipotassium salt of nitrodithioacetic acid with certain straight chain alkylamines, thereby converting only one of the KS-groups to an alkylamine group. The resulting monopotassium salt may be alkylated to produce the required N-substituted-1-alkylthio compound which may be reacted with a suitable amine to produce the histamine H.sub.2 -antagonist ranitidine.

3-Hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters which, as intermediate products that can be industrially produced in a simple manner, can be used for the production of 2-methylpyridine-5-propionic acid alkyl ester.

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Durham, United Kingdom

James Ian Grayson