Bind Therapeutics, Inc.

Infinity Pharmaceuticals, Inc.

Pfizer Corporation

Bind Biosciences, Inc.

Blossom Innovations, LLC

Other

Alkermes Controlled Therapeutics, Inc.

Lyndra Therapeutics, Inc.

Alkermes Controlled Therapeutics, Inc. Ii

Infinity Discovery, Inc.

Hawkeyepedershaab Concrete Technologies, Inc

Georgia-pacific Chemicals LLC

Computer Motion, Inc.

James I Wright

Greg Troiano

Stephen E Zale

Mir Mukkaram Ali

James R Porter

Jeff Hrkach

Roger H Pak

Christina Van Geen Hoven

Young-Ho Song

Yulun Wang

Charles Steve Jordan

Louis Grenier

Julian Adams

Yun Gao

Asimina T Georges Evangelinos

David Dewitt

Vincent Zuo

Darrin R Uecker

Edward Holson

Brian C Austad

Modjtaba Ghodoussi

Charles Holland Dresser

Kurt D Gabrielson

John B Hines

Richard Arthur Rediger

Susan C Low

Andrew Bellinger

Lisa M Arthur

Carl R White

Michael Figa

Abhimanyu Sabnis

Keith Phillip Laby

Jeff D Wilson

Paul Hart

Colin R Gardner

Dan Sanchez

Maria Figueiredo

Joe Ting

Tania To

Ben Apollonio

Hong Wang

Erick Peeke

John J Lee

Rosemary Lynn Kanasty

Warren E Jaworowicz

Nupura Bhise

Jung Hoon Yang

Jason Auer

Tarikh Christopher Campbell

Bennett Carter

Amante Mangaser

Steve Jordan

Michael J Aron

Michael J Cousin

Dave Strabala

David Altreuter

Bryan Moehle

Mike McDonald

Yong-ho Song

Kristyn Greco

Oleg Svanidze

Aaron Schmidgall

Tina Van Geen Uoven

Tina Van Geen Hoven

Susan Low

Mike Mcdonald

An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Another exemplary apparatus can include, for example, a base structure comprising a lumen extending along a length thereof, and at least one optically-transmissive layer circumferentially surrounding the base structure and provided at least at a distal end of the base structure. For example, in operation, the optically-transmissive layer can be configured to transmit a particular optical radiation at the distal end thereof toward a target tissue.

Devices, systems and methods for tissue analysis, location determination and therapy thereof using optical radiation

A tissue detection and location identification apparatus can include, a first electrically conductive layer surrounding a lumen, an insulating layer surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can surround the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for determination/detection of a tissue type, and/or determination of a location of insertion device/apparatus.

Methods for tissue analysis, location determination and therapy thereof using optical radiation

The invention provides gastric residence systems, or components of gastric residence system such as segments or elongate members of gastric residence systems, with release rate-modulating films and methods for making and using such systems. The release rate-modulating films provide good control over release of agents (such as therapeutic, diagnostic, or nutritional agents) present in the gastric residence system. The films also permit higher drug loading in the gastric residence systems and components of gastric residence systems while maintaining good control over release of agents. Some embodiments of the films can provide resistance against burst release of agent upon exposure to alcohol.

Gastric residence systems with release rate-modulating films

An overcharging protection system monitors the temperature of a cable used to transfer electricity from a power source to a personal electronic device. If the temperature as detected by a thermometer device of a sensor crosses a threshold, a bridge of a cutoff device is retracted disconnecting the two pieces of the cable to prevent any further increase in temperature due to charging. The thermometer device and cutoff device are housed in the interior space of a casing. The casing attaches to the cable.

Overheating protection system

The invention provides gastric residence systems for administration of adamantane-class drugs or pharmaceutically acceptable salts thereof, such as memantine or pharmaceutically acceptable salts thereof, and methods for making and using such systems. The systems provide extended release of drug, reducing the frequency with which the drug must be administered to the patient. The gastric residence systems, or components of gastric residence system such as segments or elongate members of gastric residence systems, can have release rate-modulating films, which provide good control over release of adamantane-class drugs or pharmaceutically acceptable salts thereof present in the gastric residence system. Some embodiments of the films can provide resistance against burst release of adamantane-class drugs or pharmaceutically acceptable salts thereof upon exposure to alcohol.

Gastric residence systems for sustained delivery of adamantane-class drugs

An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus.

Tissue detection devices, systems and methods

A continuous length of spring-steel material of a substantially round cross-section formed with a bent section comprising a radius corresponding to an outer diameter of the pipe. A hook section is combined at one end of the continuous length of spring-steel material where the hook is formed to grab one of the wires of the cage to hold the pipe in position. A lateral leg is positioned at the other end of the continuous length of spring-steel material and is formed to grab another one of the wires of the cage to the hold the pipe in position.

Lift hole forming device for concrete products

An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer. The first electrically conductive layer, the insulating layer, and the second electrically conductive layer can form a structure which has a first side and a second side disposed opposite to the first side with respect to the lumen, where the first side can be longer than the second side thereby forming a sharp pointed end via the first side at a distal-most portion. The exemplary configuration can be used for (a) determination/detection of a tissue type using impendence of the electrically conductive layers, and/or (ii) determination of a location of at least one portion of the insertion device/apparatus. Based on such determination, it is possible to effectuate ablation or heating of tissue by applying RF energy across the electrically conductive layers.

Devices, systems and methods for tissue analysis, locaton determination and tissue ablation

The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles.

Therapeutic nanoparticles comprising a protonatable nitrogen therapeutic agent and methods of making and using same

Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same

The present disclosure generally relates to a process for preparing therapeutic nanoparticles, where the process includes combining a therapeutic agent with an organic acid. The therapeutic nanoparticles may have, for example, improved drug loading and/or drug release properties.

Process for preparing therapeutic nanoparticles

The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Stable formulations for lyophilizing therapeutic particles

The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers

The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.

Drug loaded polymeric nanoparticles and methods of making and using same

The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.

Therapeutic polymeric nanoparticles with mTOR inhibitors and methods of making and using same

Growing community of inventors

Lexington, MA, United States of America

James I Wright