University of Washington

The United States of America, As Represented by the Secretary, Department of Health and Human Services

James I Mullins

George N Pavlakis

Barbara K Felber

Lawrence A Loeb

Antonio Valentin

Fusheng Li

David C Nickle

Mark A Jensen

Allen G Rodrigo

Gerald H Learn

Siriphan Manocheewa

The invention provides methods and compositions for eliciting broad immune responses. The methods employ nucleic acid vaccines that encodes highly conserved elements from a virus.

Altering the immundominance hierarchy using a DNA vaccine expressing conserved regions

Method of altering the immundominance hierarchy of HIV gag by DNA vaccine expressing conserved regions

The present invention is directed to ancestral and COT nucleic acid and amino acid sequences, methods for producing such sequences and uses thereof, including prophylactic and diagnostic uses.

Ancestral and COT viral sequences, proteins and immunogenic compositions

The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.

Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA

The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.

Induction of viral mutation by incorporation of miscoding ribonucleoside

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Seattle, WA, United States of America

James I Mullins