3m Innovative Properties Company

James I Hembre

Jerald K Rasmussen

Robert T Fitzsimons, Jr

Kannan Seshadri

George W Griesgraber

Catherine A Bothof

Simon Kelly Shannon

Peter D Wickert

Yi He

Louis C Haddad

Erin A Satterwhite

Semra Colak Atan

Kurt J Halverson

Sanjay L Patil

Daniel Sarpong

Moses Mekala David

Mahfuza B Ali

Cary A Kipke

Raj Rajagopal

Patrick L Coleman

Andrew W Rabins

Anila Prabhu

Del R Lawson

Barbara C Swenson

Taib K Ansera

Patrick S Quint

Robert T Fitzsimons

Robert TJr Fitzsimons

A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.

Ligand functional substrates

An article that can be used for biomaterial capture comprises

Ligand-functionalized substrates with enhanced binding capacity

Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.

Ligand functionalized polymers

Guanidinyl ligand-functionalized polymers, methods of making the same, and substrates bearing a grafted coating of the ligand-functional polymers are described. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, endotoxins and proteins, at pH's near or below the pI's of the biomaterials.

Graft copolymer functionalized article

A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.

Process for preparing guanidino-functional monomers

An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

Ligand functionalized substrates with enhanced binding capacity

Porous polymeric resins, reaction mixtures and methods that can be used to prepare the porous polymeric resins, and uses of the porous polymeric resin are described. More specifically, the polymeric resins typically have a hierarchical porous structure plus reactive groups that can be used to interact with or react with a variety of different target compounds. The reactive groups can be selected from an acidic group or a salt thereof, an amino group or salt thereof, a hydroxyl group, an azlactone group, a glycidyl group, or a combination thereof.

Porous polymeric resins

Growing community of inventors

Plymouth, MN, United States of America

James I Hembre