The Charles Stark Draper Laboratory, Inc.

The Brigham and Women's Hospital, Inc.

Massachusetts Institute of Technology

James Hsiao

Joseph L Charest

Jeffrey T Borenstein

Christopher M DiBiasio

Kevin Andrew Hufford

Eli J Weinberg

Peter Mack

Malinda M Tupper

Guillermo Garcia-Cardena

Ahmad S Khalil

Sarah L Tao

Bryan McLaughlin

Ernest Soonho Kim

Anilkumar Harapanahalli Achyuta

Alla Epshteyn

Tatiana Kniazeva

Vijaya Kolachalama

A multi-lumen catheter includes a primary lumen having a proximal end and a tip and a secondary lumen parallel to the primary lumen. The primary lumen and the secondary lumen share a wall. A port is defined in the wall proximate the tip of the primary lumen and provides fluidic communication between the primary lumen and the secondary lumen.

Seeping flow anti-clotting blood catheter

A catheter includes an elongated tube having a distal end and a proximal end. The elongated tube includes porous material having an interior and an exterior face. The interior face defines a lumen along a central axis of the elongated tube. The porous material is configured to flow a fluid between the interior face and the exterior face and to seep the fluid out of the porous material through the exterior face and interior face. A lining covers at least a portion of the exterior face and substantially limits perfusion through the exterior face at the portion of the exterior face covered by the lining. The catheter is impregnated with a material that prevents buildup of material on one of an inner face or an outer face of the catheter or the lining is coated with one or more of an anticoagulant, antibiotic, or antithrombotic.

Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.

Microfluidic structures for biomedical applications

The device and methods described herein relate to a seeping flow catheter. The seeping flow catheter includes a porous material. The inner face of the porous material defines the lumen of the catheter. The porous material is configured such that fluid can flow along the length of the catheter, between the inner face and outer face of the porous material. As the fluid flows through the porous material, the fluid can seep into the lumen of the catheter through the inner face or out of the catheter through the outer face of the porous material. Portions of the inner or outer face can include a lining that substantial reduces the perfusion of the fluid through the lined areas.

A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels.

Multi-layered micro-channel electrode array with regenerative selectivity

A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices.

Methods for reducing the blood priming volume and membrane surface area in microfluidic lung assist devices

microfluidic structures for biomedical applications

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Watertown, MA, United States of America

James Hsiao