Phyton Holdings, LLC

Ocean Spray Cranberries, Inc.

Natural Pharmaceuticals, Inc.

Avoca, Inc.

Natural Pharmaccuticals, Inc.

James Harvey Johnson

Rex T Gallagher

John S Juchum

Roland R Franke

Dong S Yang

Brian A Bucher

Christopher D Howe

Barry Joseph Hand

Edward M Desimone, Iii

Marc A Plante

Harold L Mantius

Lawrence E Rose

Stephen Joseph Nojeim

T G Sambandam

Paula Lent

Christopher McNamara

Margarita Gomez

Lowell Vernon Dravenstadt, Ii

Dasheng Wang

Richard J Pariza

T G Sambandan

Tg Sambandam

Barry J Haad

Marc A Plant

Edward M De Simone, Iii

The disclosure provides a method of obtaining an isolated phospholipid enriched krill composition. The method includes a) contacting a crude krill composition with an alcohol in an amount sufficient to provide a phospholipid enriched layer and a non-phospholipid enriched layer; b) forming a phospholipid enriched layer and a non-phospholipid enriched layer, wherein the phospholipid enriched layer is above the non-phospholipid enriched layer; c) isolating the phospholipid enriched layer and the non-phospholipid enriched layer; and d) removing the alcohol from the phospholipid enriched layer to provide an isolated phospholipid enriched krill composition.

Methods for the preparation of phospholipid enriched krill compositions

Methods for concentrating phenolics in a solution and compositions related to the concentrated phenolics.

Phenolics extraction and use

A method of crystallizing docetaxel is disclosed. The method comprises (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is selected from the group consisting of acetone, methyl-tert-butyl ether, tetrahydrofuran (THF), and acetonitrile and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.

Purification of taxanes

Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water.

Methods for concentrating phenolics in a solution and compositions related to the concentrated phenolics are provided. In particular, methods and compositions are described relating to concentrated phenolics obtained from cranberry feedstock extracts combined with fumaric acid as beverage additives. Additionally, methods for obtaining phenolics from feedstocks using resin absorbtion and elution are described.

Disclosed is a method of crystallizing a taxane comprising combining the taxane and methylene chloride to obtain a solution and adding an anti-solvent to the solution to obtain a crystalline taxane, wherein the anti-solvent is selected from the group consisting of hexane and heptane.

Methods for concentrating phenolics in a solution and compositions related to the concentrated phenolics are provided In particular, methods and compositions are described relating to concentrated phenolics obtained from cranberry feedstock extracts combined with fumaric acid as beverage additives Additionally, methods for obtaining phenolics from feedstocks using resin absorption and elution are described.

This invention is directed to a method for isolating and/or purifying one or more taxanes from materials comprising taxanes. In one embodiment, the method comprises the steps of: (a) treating a taxane containing material with an amino containing material attached to a solid matrix, such as a polyethyleneimine-bonded silica chromatographic resin; (b) eluting the desired taxane compound from the resin; and (c) recovering the eluted taxane compound.

Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins

The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.

Methods and compositions for converting taxane amides to paclitaxel or other taxanes

The invention provides methods and compositions for reductively deoxygenating an amide group at a C-3' position of a taxane molecule followed by subsequent intra-molecular acyl migration of an acyl group to the C-3&#x2032; position.

Conversion of taxane molecules

The invention provides methods and compositions for selectively acylating a specific hydroxyl group in a molecule of interest containing at least two unprotected secondary hydroxyl groups. Although the methods and compositions of the invention have general applicability, they are particularly useful in the selective acylation of taxane molecules.

Growing community of inventors

Edenton, NC, United States of America

James Harvey Johnson