Cytokinetics, Inc.

Other

University of California

Grip4orce, LLC

Etamota Corporation

James Hartman

Roman Sakowicz

Fady Malik

Jeffrey T Finer

Ronald D Vale

Christophe Beraud

Richard Freedman

Andrew Craven

Blake Schwartzman

Brian Y Lim

James B Kelly

John E Farmer

Brian D Hunt

Michael J Bronikowski

Robert William Graham

Eric W Wong

Mike Warren

An inorganic coating mixture for a solar panel which cures to a protective layer upon the exposed surface of the transparent sheet of material covering a photovoltaic cell of a solar panel and a method therefor. The protective layer, so formed, reduces the operating temperature of the solar panel and deters the adherence of dust and other particulate matter to the exposed surface of the transparent sheet.

Particulate adherence and temperature reducing coating for photovoltaic solar panels

An exercise grip device for use on a handle of a sport instrument which is to be swung and has a predetermined exterior size and configuration for a predetermined sport of the type swung to strike an object, wherein the handle has a predetermined cross-sectional configuration includes a generally tube-like member with a lengthwise opening and having about hand-width to permit grasping thereabout with one's hand and wherein the tube-like member includes a spring aspect which is preformed to an open relaxed position has an inner surface having a cross-sectional configuration which is larger than the predetermined cross-sectional configuration of the handle and is compressible to a closed position where the inner surface is maintained in contact with the handle to exert a force on one's hand and arm muscles and wherein the surface includes a nonmetal material which in the closed position engages the handle to prevent sliding movement therebetween by virtue of a non metal to handle contact of the grip device with the handle and while engaged by one's hand in a continuous compressed manner prevents sliding movement through the non metal to handle contact and concurrently works one's hand and arm muscles throughout a swing exercise employing the device on the instrument.

Exercise grip device

An exercise grip device includes a jaw member which is of a sufficient width to permit grasping thereabout with one's hand, wherein the jaw member includes a spring aspect which is preformed to an open position to permit receiving a weightlifting bar and is compressible to a closed position enabling engagement of the jaw member with the weightlifting bar in a manner to prevent sliding movement therebetween and while compressed exerts a force on one's hand and forearm muscles. A method includes weightlifting using the exercise grip device.

A vertical device geometry for a carbon-nanotube-based field effect transistor has one or multiple carbon nanotubes formed in a trench.

Edge-contacted vertical carbon nanotube transistor

The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.

Human smooth muscle myosin heavy chain

The present invention provides high throughput screening methods for characterizing compounds that modulate the biological activity of a biochemically functional sarcomere. Compounds characterized by such methods are useful for treating congestive heart failure.

Methods for treating congestive heart failure

This invention provides methods for the screening and identification of agents having potent effects on the progression of the cell cycle. In one embodiment, the methods involve contacting a polymerized microtubule with a microtubule severing protein or a microtubule depolymerizing protein in the presence of an ATP or a GTP and a test agent; and (ii) detecting the formation of tubulin monomers, dimers or oligomers. The p60 subunit of katanin provides a particularly preferred microtubule severing protein possessing both ATPase and microtubule severing activities.

Assays for the detection of microtubule depolymerization inhibitors

Methods for purifying actin are provided. The methods generally involve the addition of a magnesium salt in a sufficient quantity, whereby G-actin polymerizes to form actin paracrystals, which can be recovered as a purified form of actin.

Methods for purifying actin

This invention provides assays for agents that modulate (e.g. upregulate, downregulate or completely inhibit) microtubule depolymerizing or microtubule severing proteins. Such agents will have profound effects on progression of the cell cycle and act as potent anti-mitotic agents. The microtubule severing protein or microtubule depolymerizing protein is preferably a katanin, a p60 subunit of a katanin, an XKCM 1, or an OP18 polypeptide.

The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.

Sarcomere protein composition

High throughput sarcomeric assay

This invention provides methods for the screening and identification of agents having potent effects on the progression of the cell cycle. In one embodiment, the methods involve contacting a polymerized microtubule with a microtubule severing protein or a microtubule depolymerizing protein in the presence of an ATP or a GTP and a test agent; and detecting the formation of tubulin monomers, dimers or oligomers. The p60 subunit of katanin provides a particularly preferred microtubule severing protein possessing both ATPase and microtubule severing activities.

Growing community of inventors

San Francisco, CA, United States of America

James Hartman