Saluda Medical Pty Limited

James Hamilton Wah

John Louis Parker

Dean Michael Karantonis

Milan Obradovic

Robert Bruce Gorman

Peter Scott Vallack Single

Amol Malla

An implantable device is configured to control application of a neural stimulus as defined by a stimulus parameter; measure via the measurement circuitry a characteristic of a neural compound action potential response evoked by the stimulus; and compute, using the stimulus parameter and the measured characteristic of the evoked neural compound action potential response, a characteristic of an evoked response that would be obtained from the neural stimulus if the patient were in a reference posture. A posture of the patient can be estimated from the computed characteristic and/or the computed characteristic can be used as a feedback variable of a feedback loop. Multidimensional histograms of datasets comprising at least one of the stimulus parameter and a feedback variable can be stored.

Neurostimulation responsive to posture

An automated method of controlling neural stimulation. A neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway, and the stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable such as observed ECAP voltage (V) is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value for a future stimulus. The method adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway. A compensating transfer function is applied to the feedback variable, the compensating transfer function being configured to compensate for both (i) a distance-dependent transfer function of stimulation, and (ii) a distance dependent transfer function of measurement which is distinct from (i).

Feedback control of neuromodulation

An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.

Method and apparatus for estimating neural recruitment

An implantable device for controlling electrical conditions of body tissue. A feedback sense electrode and a compensation electrode are positioned proximal to the tissue to make electrical contact with the tissue. A feedback amplifier is referenced to ground, and takes as an input a feedback signal from the feedback sense electrode. The output of the feedback amplifier is connected to the compensation electrode. The feedback amplifier thus drives the neural tissue via the compensation electrode in a feedback arrangement which seeks to drive the feedback signal to ground, or other desired electrical value.

Method and system for controlling electrical conditions of tissue

A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.

Growing community of inventors

Artarmon, Australia

James Hamilton Wah