The United States Of America, As Represented By The Secretary, Department Of Health And Human Services

Starks Associates Inc.

The United States Of America As Represented By The Department Of Health

James Halpern Doroshow

Charles Theodore Kane, Jr

Jiamo Lu

Krishnendu Roy

Md Tafazzal Hossain

Prabhakar Risbood

Thomas D Pfister

Robert J Kinders

Ralph E Parchment

Allison M Marrero

Jaimo Lu

Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.

Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof

Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding fragments, conjugates thereof, and the use of these antibodies, antigen binding fragments and conjugates are disclosed herein. Also disclosed are nucleic acids encoding these antibodies, vectors including these antibodies, and isolated host cells transformed with these nucleic acids and vectors. Methods are also disclosed for using these antibodies, such as to detect pT1989 ATR, or to determine the dose of an agent of use to treat a subject. The antibodies are also of use for identifying ATR inhibitors.

Antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 and their use

Growing community of inventors

Bethesda, MD, United States of America

James Halpern Doroshow