Biocode, Inc.

Ciba-geigy Corporation

Isk Biosciences Corporation

James H Rittenburg

Frank P Petersen

Sally A Miller

G David Grothaus

Mark D Clymer

Michael G Pappas

Donna A Fitzpatrick

Robin Jenkins

Frank G Angella

Bharat B Kikani

A method of determining the concentration of an analyte in a sample, said method comprising bringing said analyte in contact with an indicator zone comprising a concentration gradient of a mobile binding member; and bringing said mobile binding member gradient into operable contact with a test zone comprising a fixed binding member, wherein a detectable signal that indicates the concentration of said analyte is produced.

Analyte detection with a gradient lateral flow device

A method of monitoring a therapeutic regimen in an animal, the method involving a) providing to the animal a therapeutic compound and a detectable compound that passes into the bloodstream, excretory system, or other tissue or body fluid in detectable form; b) after a period of time, following step (a), sufficient for passage of a detectable amount of the detectable compound into the body fluid or tissue, collecting a sample of the fluid or tissue from the animal; and c) measuring or detecting the detectable compound, or a detectable metabolite thereof, in the sample, wherein the detectable compound involves one member of a specific binding pair, and detection is carried out using the second member of the specific binding pair.

Marking of orally ingested products

In general, the invention features a method of marking a product for identification in which a marker, composed of a print molecule, print molecule analogue, or molecularly imprinted molecule, are added to the product and subsequently measured in a specific binding assay.

Marking of products to establish identity, source and fate

Methods for determining the concentration of an analyte in a sample in which an analyte gradient is established and brought into contact with one or more zones that contain binding members that interact with the analyte and thereby produce a detectable signal. Devices that may be used to practice the disclosed methods are also provided.

Novel derivatives of chlorothalanil.RTM. (tetrachloroisophthalonitrile, TCPN), permit conjugation of the TCPN derivative to a carrier useful as an immunogen to induce antibodies specific for TCPN or a TCPN metabolite, or a screening antigen to detect such antibodies. Polyclonal and monoclonal antibodies specific for TCPN or a TCPN metabolite, as well as hybridoma cells producing such antibodies are disclosed. Also provided are immunoassay methods for detection and quantitation of pesticide chemicals, in particular, the fungicide TCPN or a TCPN metabolite, and kits containing a TCPN derivative screening antigen, an anti-TCPN or anti-TCPN metabolite antibody useful for performing the immunoassays.

Immunoassay for tetrachloroisophthalonitrile (chlorothalonil), its

The invention relates to monoclonal antibodies that react specifically with members of the genus Mycosphaerella and hybridomas that produce such antibodies. The invention is further directed to a method for making a hybridoma cell line that produces monoclonal antibodies that react specifically with at least one species of Mycosphaerella, and a method of obtaining monoclonal antibodies therefrom. Methods and kits for diagnosing Mycosphaerella infections in plant material using such monoclonal antibodies are also within the scope of the invention.

Monoclonal antibodies to mycosphaerella species

The invention relates to monoclonal antibodies that react specifically with members of the genus Leptosphaeria and hybridomas that produce such antibodies. The invention is further directed to a method for making a hybridoma cell line that produces monoclonal antibodies that react specifically with Leptosphaeria nodorum, and a method of obtaining monoclonal antibodies therefrom. Methods and kits for diagnosing Leptosphaeria infections in plant material using such monoclonal antibodies are also within the scope of the invention.

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Perkasie, PA, United States of America

James H Rittenburg