Microchips, Inc.

Boston Scientific Scimed, Inc.

James H Prescott

Scott Albert Uhland

John T Santini, Jr

Stephen Jack Herman

Benjamin F Polito

Dennis Ausiello

John M Maloney

Timothy Kreiger

Elizabeth R Proos

Mark A Staples

John T Santini

Timothy Krieger

Elizabeth Rees Proos

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

Implantable device for controlled, extended delivery of parathyroid hormone

Method and device for the controlled delivery of parathyroid hormone

Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.

Control of drug release by transient modification of local microenvironments

Growing community of inventors

Cambridge, MA, United States of America

James H Prescott