Neurorepair, Inc.

University of California

James H Fallon

James Steven Reid

Richard M Kinyamu

William C Tang

William E Bunney

Ryan Langan

A neural probe device includes a housing configured to receive a nerve fiber of a subject and an anchor disposed within the housing and configured to fix the nerve fiber relative to the housing. The device further includes a plurality of actuatable, moveable electrodes disposed in the housing along a length of the nerve fiber, each moveable electrode comprising a plurality of projections containing one or more electrodes thereon, wherein actuation of the moveable electrode causes the moveable electrode to move generally transverse to a long axis of the nerve fiber and penetrate the nerve fiber with the plurality of projections. The device is also optionally configured to inject a growth factor into the nerve fiber to maintain the viability of the nerve fiber.

Neural probe array and method of use

The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) with a polypeptide that binds the epidermal growth factor (EGF) receptor and directing progeny of the proliferating progenitor cells to migrate en masse to a region of the CNS in which they will reside and function in a manner sufficient to reduce the neurological deficit. The method may include a further step in which the progeny of the neural precursor cells are contacted with a compound that stimulates differentiation.

Methods for treating neurological deficits

The invention provides methods of treating a subject having a disease, disorder or condition of the central nervous system. The methods include administering TGF-&#x3b1; polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating progenitor cell or stem cell proliferation, migration and differentiation. The methods of the invention are useful to treat and prophylactically ameliorate neurological tissue injury in vivo.

Methods for treating a neurological disorder by peripheral administration of a trophic factor

Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a)

Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-&#x3b1;)

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Irvine, CA, United States of America

James H Fallon