American Cyanamid Company

James H Boothe

Martin L Sassiver

Adma S Ross

William V Curran

This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.

Derivatives of 3-(formylmethylthio)-propanoate

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R.sub.2 is selected from the group hydrogen, amino, C.sub.1 to C.sub.6 alkylamino and di-C.sub.1 to C.sub.6 alkylamino and R.sub.3, R.sub.4 and R.sub.5 are the same or different and are selected from the group hydrogen, hydroxy, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R.sub.3 and R.sub.4 or R.sub.4 and R.sub.5 taken together are the moiety --CH.sub.2 (CH.sub.2).sub.2 CH.sub.2 --.

Cephalosporanic acid derivatives

This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido ]penicillanic acids which possess antimicrobial activity.

7-[D.alpha.-(Coumarin-3-carboxamido)arylacetamido]-cephalosporanic acids

This disclosure describes compounds of the class of 6-[D-.alpha.-(benzocoumarin-3-carboxamido)phenylacetamido] penicillanic acids which possess antimicrobial activity.

6-[D-.alpha.-(Coumarin-3-carboxamido)arylacetamido]-penicillanic acids

This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido]penicilla nic acids which possess antimicrobial activity.

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Montvale, NJ, United States of America

James H Boothe