Southwest Research Institute

Surmodics, Inc.

Gore Enterprise Holdings, Inc.

Promed Pharma, LLC

James H Arps

Geoffrey Dearnaley

Ronghua Wei

Christopher Rincon

Andrew G Bach

Kent Edward Coulter

Carlos Alberto Cavalca

John S Campbell

Ralph A Chappa

Michael A Miller

James Lankford, Jr

Edward Langa

Kuang-Tsan Kenneth Chiang

Gerald R Leverant

Richard Page

Mahesh Murthy

Carlos Cavalca

Matthew Petersen

Chistopher Rincon

Thomas L Booker

The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

Insertable medical devices having microparticulate-associated elastic substrates and methods for drug delivery

Pharmacologically active implants, in particular subcutaneous implants, intrauterine devices, and intravaginal rings, are provided herein. Methods for forming an active ingredient-containing core are described. Methods for laminating an active ingredient-containing core to form a rate-controlling sheath are also described.

Methods for manufacturing implants

The invention relates to systems and methods for applying coatings to devices. In an embodiment, the invention includes a coating apparatus including a mandrel having a lengthwise axis and an exterior surface, the exterior surface of the mandrel defining a plurality of channels disposed parallel to the lengthwise axis, the mandrel configured to rotate around the lengthwise axis; and a spray head configured to direct a stream of material at the mandrel. In an embodiment the invention includes a method of applying a coating to a medical device. Other embodiments are also included herein.

Coating application system with shaped mandrel

The present invention relates to nanostructured material capable of storing hydrogen. The nanostructured material may be configured with a selected geometry to provide the capability to influence and increase the limiting or theoretical gravimetric storage level (GSL) of hydrogen for a given chemical composition.

Nanoengineered material for hydrogen storage

The present invention is directed to a composite particle that is microscopically two-dimensional with a third nanoscopic dimension, and to methods of making same. The particle may include a support and a metal layer. The metal layer may be catalytically active such that the particle is adapted to act as a catalyst.

Two-dimensional composite particle adapted for use as a catalyst and method of making same

The present disclosure relates to a coating and a method of applying such coating that may include nanocrystals of a transition metal compound embedded in an amorphous phase or layered structure of transition metal compounds with an amorphous phase. The transition metal compound may be selected from the group consisting of metal nitrides, metal carbides, metal silicides and combinations thereof. The amorphous matrix may include a ceramic.

Erosion resistant coatings

The present disclosure relates to a method for plasma ion deposition and coating formation. A vacuum chamber may be supplied, wherein the vacuum chamber is formed by a hollow substrate having a length, diameter and interior surface. A plasma may be formed within the chamber while applying a negative bias to the hollow substrate to draw ions from the plasma to the interior surface of the hollow substrate to deposit ions onto the interior surface and forming a coating. The coating may have a Vickers Hardness Number (Hv) of at least 500.

Plasma immersion ion processing for coating of hollow substrates

This invention is directed to a method of preventing oxidation of copper alloys at high temperatures by deposition of a nano-structured, low-chromium copper-chromium protective coating to copper-alloy components. The coatings of the present invention are applied by an ion beam assisted, electron beam physical vapor deposition and consist of copper and chromium particles having a diameter of about 10 nm. This invention also encompasses the coated copper-alloy components produced by the disclosed deposition methods.

Nanostructured low-Cr Cu-Cr coatings for high temperature oxidation resistance

Tubular structures having aspect ratios of at least about 3 and comprising interior surfaces comprising substantially uniform coatings generated from a gaseous precursor material.

Tubular structures with coated interior surfaces

Fuel cell electrodes comprising a minimal load of catalyst having maximum catalytic activity and a method of forming such fuel cell electrodes. The preferred method comprises vaporizing a catalyst, preferably platinum, in a vacuum to form a catalyst vapor. A catalytically effective amount of the catalyst vapor is deposited onto a carbon catalyst support on the fuel cell electrode. The electrode preferably is carbon cloth. The method reduces the amount of catalyst needed for a high performance fuel cell electrode to about 0.3 mg/cmor less, preferably to about 0.1 mg/cm. The electrocatalytic layer formed comprises unique, rod-like structures.

Catalytic coatings and fuel cell electrodes and membrane electrode assemblies made therefrom

This invention is a method of forming a nitride layer on at least one metal or metal alloy biomedical device, comprising: providing a vacuum chamber with at least one biomedical device positioned thereon on a worktable within the vacuum chamber; reducing the pressure in the vacuum chamber; introducing nitrogen into the vacuum chamber so that the pressure in the vacuum chamber is about 0.01 to about 10 milli-Torr; generating electrons within the vacuum chamber to form positively charged nitrogen ions; providing a negative bias to the worktable so that the positively charged nitrogen ions contact the biomedical devices under conditions such that a nitride layer forms on the at least one prosthetic device.

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San Antonio, TX, United States of America

James H Arps