The Penn State Research Foundation

Other

Ferro Corporation

Advanced Power Devices, Inc.

James H Adair

Mark Kester

Peter C Eklund

Erhan I Altinoglu

Thomas Stover

Tao Lowe

Young Shin Kim

Thomas T Morgan

Brian M Barth

Thomas R Shrout

Jill P Smith

Randy S Haluck

Yoshiya Fujiwara

Hajime Goto

Terumi Furuta

William Benjamin White

Mike S H Chu

Xiangdong Feng

Carlo Pantano

Gary L Messing

Richard E Tressler

Mary Frecker

Abraham Mathew

Gail L Matters

Alan J Snyder

Christopher A Siedlecki

Timothy J Russin

David L Shelleman

Sriram S Shanmugavelandy

Jennifer A Nelson

Julie M Anderson

Kishore Sreenivasan

Heber E Rast, Iii

Christopher J Szepesi

Harriet Black Nembhard

Tarah M Pecora

Michael M Mandanas

Lawrence Sinoway

Victor Ruiz-Velasco

Erwin Vogler

Sarah M Rouse

Mylisa Parette

Danielle Asquino

Kari Eyer

Jeff Davidson

Rahul Sharma

James M Kaiser

Christopher McGovern

James M D Kaiser

Christopher Muhlstein

Eric Mockensturm

Nicholas Antolino

Gregory R Hayes

Milton Aguirre

Rebecca Kirkpatrick

Chumpol Yuangyai

Jun Wang

Alan Snyder

Christopher Siedlecki

Victor Hershey Medical Center Ruiz-Velasco

Stable, non-toxic, calcium phosphate nanoparticles are formed that incorporate one or more oligonucleotides. RNAi nucleotides may be incorporated and, in particular, siRNA nucleotides. Since the siRNA nanoparticles dissociate leaving only naturally occurring residual materials, calcium and phosphate, along with the siRNA, they are particularly useful as carrier vehicles. The ability to incorporate more than one siRNA provides a means to block or knock down the translation of multiple targeted proteins at the same time.

Therapeutic calcium phosphate nanoparticle incorporating siRNA useful in treating disease

A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.

Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds

Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents are protected from interaction with the environment at normal physiological pH. However, once the CPNPs have been taken up, at intracellular pH, the CPNPs dissolve releasing the agent. Thus, chemotherapeutic or imaging agents are delivered to specific cells and permit the treatment and/or imaging of those cells. Use of the bioconjugated CPNPs both limits the amount of systemic exposure to the agent and delivers a higher concentration of the agent to the cell. The methods and principals of bioconjugating CPNPs are taught by examples of bioconjugation of targeting molecules for breast cancer, pancreatic cancer, and leukemia.

Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo

Nano-encapsulated photosensitizers and their use in the treatment of tumors and/or imaging is described. Preferably, the photosensitizers are encapsulated in a calcium phosphate nanoparticle (CPNP). Encapsulating the PS in a CPNP increases the half-life of the PS, increases absorption of the PS into the target cell tissue, increases the photostability of the PS, increases the photoefficiency of the PS, increases in vivo retention of the PS, or combinations thereof, ultimately making it a highly efficacious agent for use in photodynamic therapy, imaging target tissues, vessels, or tumors, and/or detecting or locating tumors.

In vivo photodynamic therapy of cancer via a near infrared agent encapsulated in calcium phosphate nanoparticles

An IV hanger providing a portable adjustable hanging attachment for conventional intravenous equipment comprises an attachment method, a pulley system, and a hanging bracket. The attachment method comprises a plurality of attachment means for attaching the apparatus to an elevated structure. The attachment method is integrally connected to a pulley system which allows a user to selectively adjust the height of the hanging bracket relative to the frame. The hanging bracket provides a plurality of attachment hooks for support of IV equipment. The apparatus is particularly adapted for veterinary field calls where ground-based support system are prone to damage or disturbance by animal patients.

Portable intravenous device and hanger therefor

A polycrystalline mesoscale component, formed through a process including filing a mold cavity formed in a photoresist with a mold fill, is provided with an overall length L divided into multiple segments with a second segment extending from a first segment at a nonlinear angle. The first segment has a first segment height H1 and a first segment thickness T1, while the second segment has a second segment height H2 and a second segment thickness T2, with the lesser of H1 and H2 defining a minimum segment height Hmin and the lesser of T1 and T2 defining a minimum segment thickness Tmin. The resultant component has a ratio of L:Hmin:Tmin of 20-80:1:0.5-10 where Hmin is between 5 and 500 microns. In specific instances, the nonlinear angle is acute, the multiple segments are rectilinear in cross section, and a segment thickness has an edge resolution of between 0.1 and 2 microns.

Polycrystalline complex-shaped mesoscale components

The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm.

Unagglomerated core/shell nanocomposite particles

The present invention provides a method of removing spectator ions and contaminants from aqueous suspensions of solid particles. In accordance with the method of the invention, the solid particles are transported across a phase boundary into a non-polar organic solvent, leaving the spectator ions and contaminants in the aqueous phase. To facilitate the efficient transportation of the solid particles across the phase boundary, the surface of the solid particles is coated with an amphiphilic polyelectrolyte. If desired, the solid particles can be recovered from the organic phase by evaporating the organic solvent.

Method of removing spectator ions from aqueous suspension of solid particles

A hydrogen storage material includes a nano size material that can be formed in a multi-layered core/shell structure and/or in a nanotabular (or platelet) form.

Hydrogen storage material based on platelets and/or a multilayered core/shell structure

Solid, shaped and fired fibers of TiOand TiOare made by firing TiOfibers in a reducing atmosphere. In a first aspect, the TiOfibers are made by extruding into air a viscous TiOgel and heat treating the resulting green fibers to remove solvent, decompose and to volatilize undesired constituents to form electrically conductive, refractory fibers of TiOand TiO. In a second aspect, solid, shaped and fired fibers of TiOand TiOare made by firing extruded fibers from mixtures of TiO.

Electrically conductive fibers of Ti4O7 and Ti5O9

Chemically aided milling of ceramic powders is disclosed. Carrier suspension, usually aqueous, of the ceramic powder may have added to it a dispersing agent and a passivating agent, followed by milling the aqueous suspension while continuously monitoring the pH, and as necessary, adding acid or a base to keep the pH within a desired range during milling. Real time monitoring allows milling with lower energy consumption, and enhances the desirable particle surfaces of the ceramic powder. The passivating agent can also be real time monitored and adjusted as necessary.

Dynamic control and enhanced chemical milling of ceramics to submicron particle sizes

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University Park, PA, United States of America

James H Adair