Albany Molecular Research, Inc.

Harmony Biosciences, Inc.

Curia Global, Inc.

James Grabowski

Peter Guzzo

May Xiaowu Jiang

Matthew Surman

Alan John Henderson

Mark Hadden

Alexander Usyatinsky

Matthew David Surman

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein Ris H or optionally substituted alkyl; R, R, Rare each independently selected from H, &#x2014;O-alkyl, &#x2014;S-alkyl, alkyl, halo, &#x2014;CF, and &#x2014;CN; G is &#x2014;CRR&#x2014;NR&#x2014; or &#x2014;NR&#x2014;CRR; Ris H, optionally substituted alkyl, optionally substituted heterocycle, &#x2014;C(&#x2550;O)&#x2014;R, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;R, or &#x2014;C(&#x2550;O)&#x2014;NRR; Rand Rare each optionally substituted alkyl or optionally substituted heterocycle; R, R, R, R, R, R, Rand Rare each independently selected from H or optionally substituted alkyl; Rand Rare each independently H or halogen; L is &#x2014;CH&#x2014;O&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

(1-azinone)-substituted pyridoindoles

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein Ris H or optionally substituted alkyl; R, R, Rare each independently selected from H, &#x2014;O-alkyl, &#x2014;S-alkyl, alkyl, halo, &#x2014;CF, and &#x2014;CN; G is &#x2014;CRR&#x2014;NR&#x2014; or &#x2014;NR&#x2014;CRR; R; is H, optionally substituted alkyl, optionally substituted heterocycle, &#x2014;C(&#x2550;O)&#x2014;R, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;R, or &#x2014;C(&#x2550;O)&#x2014;NRR; Rand Rare each optionally substituted alkyl or optionally substituted heterocycle; R, R, R, R, R, R, Rand Rare each independently selected from H or optionally substituted alkyl; Rand Rare each independently H or halogen; L is &#x2014;CH&#x2014;O&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Growing community of inventors

Castleton on Hudson, NY, United States of America

James Grabowski