Biocon Limited

Nobex Corporation

James Gordon Still

Nnochiri Ekwuribe

Christopher H Price

Jennifer Ann Filbey

Balasingam Radhakrishnan

Aslam M Ansari

Amy L Odenbaugh

Gordana Kosutic

Nnochiri N Ekwuribe

The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.

Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus

Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin polypeptide-oligomer conjugate of formula V to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may 'activate' the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.

Insulin conjugates for treating diabetes mellitus

Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may 'activate' the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.

Methods of treating diabetes mellitus

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Raleigh, NC, United States of America

James Gordon Still