Hoffmann-la Roche Inc.

James Gordon Christenson

Benjamin Pecherer

Sidney Teitel

Harvey Gurien

Richard Robert Muccino

Richard William Avenia

Novel hapten compositions consisting of 4-[4-[2-(aminopropyl)]phenyl]butanoic acid and its N-methyl derivative are useful in preparing immunogens which can be respectively employed in the elicitation of antibodies selective to amphetamine and methamphetamine. These antibodies can be used as reagents in immunoassays for these two compounds.

Hapten compositions

A sensitive radioimmunoassay for methaqualone and its major metabolites is described. Included within this disclosure is the preparation of novel methaqualone haptens, the preparation of antigens from such haptens by coupling to an immunogenic carrier material, the use of such antigens to elicit antibodies selective to methaqualone and its major metabolites and an improved radiolabelled derivative of a methaqualone analog used in the practice of said radioimmunoassay.

N-[3-methyl-4-(2-methyl-4-oxo-3,4-dihydro-quinazolin-3-y

Radioimmunoassay for methaqualone

A radioimmunoassay for cocaine and the cocaine metabolite benzoylecgonine is described. The assay utilizes a novel labelled compound .sup.125 I-4-hydroxybenzoylecgonine.

Radioimmunoassay for benzoylecgonine

The present disclosure relates to tritiated labeled benzoylecgonines. The labeled benzoylecgonines described herein are useful in immunoassays for benzoylecgonine, a metabolite of cocaine.

Tritiated O-benzoylecgonine

Antibody specific to methaqualone and its metabolites

A novel derivative of ecgonine is described. This compound, 4-hyroxy-benzoyl ecgonine, is useful as a substrate for iodination with a radioactive isotope of iodine such as .sup.125 I. The resulting radiolabeled compound is useful in a radioimmunoassay for benzoyl ecgonine.

Ecgonine derivative

New hapten compositions useful in preparing antigens which may be employed in eliciting antibodies useful in an improved radioimmunoassay for pharmacologically active phenethylamines are disclosed. Particular phenethylamins which are preferably detected by the present radioimmunoassay include the catecholamines such as norepinephrine, dopamine and epinephrine, and the amphetamines.

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North Caldwell, NJ, United States of America

James Gordon Christenson