Pfizer Corporation

Reviral Limited

James Good

George Stuart Cockerill

Edward Cochrane

Stuart George Cockerill

Matthew Barrett

Craig Alex Avery

Andrew Joseph Warner

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; Ris H, C-Calkyl or —NHR; either (i), a, c and c are all bonds, with, b, d and f absent; or b, d, and f are all bonds, with a, c, and c absent; Ris H or a group selected from C-Calkyl, C-Ccycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; Ris H or halo; Ris —OR, —NRRor —R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl and 4- to 10-membered heterocyclyl, the group being unsubstituted or substituted; n is 1 or 2; and one of V, W and X is N or CH and the other two are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Pharmaceutical compounds

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; either (i) T is N, Z is C,andare bonds, andandare absent; or (ii) T is C, Z is N,andare bonds, andandare absent; each of Rand Ris independently halo, —OR, —NRR, —COR, —C(O)OR, —CON(R)or —R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl, C-Caryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; Ris H or C-Calkyl, each Rbeing the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Benzodiazepine derivatives of formula (I): (I) wherein: each of Rand Ris independently H or halo; either (i) T is N, Z is C, -a- and -c- are bonds, and -b- and -d- are absent; or (ii) T is C, Z is N, -b- and -d- are bonds, and -a- and -c- are absent; each of Rand Ris independently halo, &#x2014;OR, &#x2014;NRR&#x2014;COR, &#x2014;C(O)OR, &#x2014;CON(R)or &#x2014;R; Ris H or halo; each of Rand Ris independently H or a group selected from C-Calkyl, C-Ccycloalkyl, C6-C10 aryl, 4- to 10-membered heterocyclyl and 4- to 10-membered heteroaryl, the group being unsubstituted or substituted; Ris H or C-Calkyl, each Rbeing the same or different when two are present; n is 0 or 1; and one of V, W, X and Y is N or CH and the other three are CH; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

Benzimidazole derivatives of formula (I): (Formula (I)) wherein: Ris &#x2014;(CH)&#x2014;R, (Formula (II)) or (Formula (III)); Ris H, halo, &#x2014;(CH)&#x2014;NH, &#x2014;(CH)&#x2014;C(&#x2550;NH)&#x2014;NHor &#x2014;(CH)&#x2014;NH&#x2014;(CH)&#x2014;NHR; Ris H, F or Cl; each of R, Rand Ris independently H or F; Ris C-Calkyl, CF, &#x2014;SOR, &#x2014;NH&#x2014;(CH)&#x2014;(NH)&#x2014;R, &#x2014;NH&#x2014;CH(RR) or a group of the following formula (A): (Formula (A)): W is &#x2014;(CH)&#x2014;, &#x2014;CH&#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;S&#x2014;CH&#x2014;, &#x2014;(CH)&#x2014;S(O)&#x2014;CH&#x2014; or &#x2014;(CH)&#x2014;NR&#x2014;CH&#x2014;; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; Ris H, &#x2014;SOR, &#x2014;SOCF, &#x2014;COR, &#x2014;C(O)OR, &#x2014;CON(R)or &#x2014;(CH)SOR; Ris H or C-Calkyl, each Rbeing the same or different when two are present; Ris &#x2014;SOR, &#x2014;SOCF, &#x2014;COR, &#x2014;CON(R)or &#x2014;(CH)SOR; and Ris C-Calkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Benzimidazole derivatives of formula (I): wherein: Ris &#x2014;(CH)m-Ror Ris halo, &#x2014;(CH)&#x2014;NHor &#x2014;(CH)&#x2014;C(&#x2550;NH)&#x2014;NH; Ris H or F; Ris &#x2014;NH&#x2014;(CH)&#x2014;(NH)&#x2014;R, &#x2014;NH&#x2014;(CHRR) or a group of the following formula (A): (A) W is &#x2014;(CH)&#x2014;, &#x2014;CH&#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;S&#x2014;CH&#x2014;, &#x2014;(CH)&#x2014;S(O)&#x2014;CH&#x2014; or &#x2014;(CH)&#x2014;NR&#x2014;CH&#x2014;; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is O and V is N; q is 0 or 1; r is 0 or 1; Ris H, &#x2014;SOMe, &#x2014;SOEt, &#x2014;SOCF, &#x2014;COMe, &#x2014;CONMe, &#x2014;CONHor &#x2014;CHCHSOMe; Ris H or C-Calkyl; and Ris &#x2014;SOMe, &#x2014;SOEt, &#x2014;SOCF, &#x2014;COMe, &#x2014;CONMe, &#x2014;CONHor &#x2014;CHCHSOMe; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

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Stevenage, United Kingdom

James Good