Boehringer Ingelheim (canada) Ltd.

Universitéde Montreal

Zealand Pharma A/s

Bristol-myers Squibb Compnay

Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

James Gillard

Pierre Louis Beaulieu

George Kukolj

Gulrez Fazal

Marc-André Poupart

Volkhard Austel

Jean Rancourt

Eric Jolicoeur

Youla S Tsantrizos

Marc-Andre Poupart

Martin Poirier

Sylvie Goulet

Andrew Roughton

Gaoqiang Yang

Jennifer L Hickey

Adam Paul Kafal

Manuel Perez Vazquez

M Monzur Morshed

Edward H Ruediger

Wu Yang

Eldon Scott Priestley

Xiaojun Zhang

Rejean Ruel

Jeremy M Richter

Sasmita Tripathy

Oz Scott Halpern

Wen Jiang

Samuel Kaye Reznik

Georg Dahmann

Wolfgang Wienen

Henning Priepke

Kai Gerlach

Herbert Nar

Roland Pfau

Annette Schuler-Metz

Martin Duplessis

Sandra Handschuh

Clint A James

Lee Fader

Eckhart Bauer

Carl Thibeault

Mathieu Parisien

Sai Kumar Chakka

Louis Morency

Sébastien Morin

Narendra Patel

Andrew L Roughton

Sebastien Morin

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Biarylmethyl heterocycles

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or &#x3b2;-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

There is described herein antagonists of &#x3b1;4&#x3b2;7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R, R, R, R, R, R, Rand Rare various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; &#x2014;C&#x2550;O&#x2014; adjacent L is the carboxy terminus of an amino acid; and L along with Z and &#x2014;C&#x2550;O&#x2014; is a peptide. 

Cyclic peptides targeting alpha-4-beta-7 integrin

There is described herein use of a compound of formula (I) below to make cyclic peptides. 

Fragment synthesis of substituted cyclic peptides

Compounds of Formula (I) wherein n, R, R, R, Rand Z are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection. 

Inhibitors of cytomegalovirus

An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: wherein Rand Rand Q are as defined herein;

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein:

A compound of the formula I: wherein: X is CH or N; Y is O or S; Z is OH, NH, NMeR, NHR; ORor 5- or 6-membered heterocycle, having 1 to 4 heteroatoms selected from O, N and S, said heterocycle being optionally substituted with from 1 to 4 substituents; A is N, CORor CR, wherein Ris H, halogen, or (C) alkyl and Ris H or (Calkyl), with the proviso that X and A are not both N; Ris H, halogen, (Calkyl) or OR, wherein Ris H or (Calkyl); The compounds of the invention may be used as inhibitors of hepatitis C virus replication. The invention further provides a method for treating or preventing hepatitis C virus infection.

Substituted carboxylic acid amides of general formula wherein A, B, and Rto Rare as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, such as antithrombotic activity and factor Xa-inhibiting activity.

Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions

Growing community of inventors

Rosemere, Canada

James Gillard