Bristol-myers Squibb Compnay

Neurogen Corporation

James G Tarrant

Harold A Mastalerz

John F Kadow

Mark George Saulnier

Qiufen May Xue

Mark D Wittman

Upender Velaparthi

Kurt Zimmermann

Anne Marinier

David Bertil Frennesson

Neelakantan Balasubramanian

Peiying Liu

Xiaopeng Sang

Stephan Roy

Karen M Stoffan

Alan J Hutchison

Bertrand Leo Chenard

Linda M Gustavson

Gregory D Vite

John M Peterson

George P Luke

Kyungae Lee

Joydeep Kant

Manuka Ghosh

Guifen Zhang

Guiying Li

Dario Doller

Wallace C Pringle

William C Rose

Mary-Margaret E O'Donnell

Steven Hansel

Mary Edson Zoeckler

Compounds of Formula I are provided, in which variables are as described herein:  Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

Substituted 1-benzyl-4-substituted piperazine analogues

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.

Tyrosine kinase inhibitors

A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents

Process for the preparation of C-4 carbonate taxanes

The present invention provides compounds of formula Iand pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

C-5 modified indazolylpyrrolotriazines

C-4 carbonate taxanes

Growing community of inventors

Hamden, CT, United States of America

James G Tarrant