Monell Chemical Senses Center

University of Pennsylvania

Mallinckrodt, Inc.

James G Kostelc

George Preti

John N Labows

George R Huggins

Kenneth J McGinley

Joseph Tonzetich

Amelia G Lukitsch

Ronald Daniele

Philip R Zelson

A leak testing system () for medicament sachets () is disclosed. The system () includes a base section () having a flat surface (). A plurality of guide rods () extend from this flat surface () of the base section (). A press section () incorporates a plurality of through-holes () that are used to movably mount the press section () on the noted guide rods (). The press section () includes a flat surface () that is maintained in at least substantially parallel relation to the flat surface () of the base section (). A medicament pouch () may be compressed between these flat surfaces () of the base section () and the press section () by sliding the press section () along the guide rods () and in the direction of the base section (). Multiple press plates can be added to adjust the force and weight to test for leaks.

Medicament sachet leak testing system

A novel method of detecting and diagnosing lung cancers by monitoring and analyzing expired lung air for the presence of selected aromatic amines, particularly aniline and ortho-toluidine, is provided.

Method of detecting the presence of bronchogenic carcinoma by analysis

Method for precisely ascertaining the time of ovulation by monitoring the concentration of alcohols in the range of C.sub.10 -C.sub.16, particularly dodecanol. A spike in the concentration of such compound(s) is indicative of time of ovulation.

Method detecting ovulation by monitoring dodecanol concentration in

A novel method of detecting and diagnosing Pseudomonas aeruginosa infections by monitoring sample headspace concentrations of selected methyl ketones, particularly 2-nonanone and 2-undecanone. In an alternate embodiment, such diagnosis may be made by monitoring the headspace concentration of methyl mercaptan to diagnose the extent of a Pseudomonas aeruginosa infection. Expeditious methods for increasing such concentrations are also disclosed which include additions of selected nutrients to incubated sample mixtures.

Method of detecting Pseudomonas aeruginosa infections utilizing selected

A novel method of diagnosing periodontal disease is disclosed wherein telltale pyridine and alkyl-pyridine compounds which are detected in the oral cavity are indicative of periodontal disease. An alternate embodiment method is disclosed wherein increased concentrations of certain other compounds are detected to confirm the presence of periodontal disease.

Growing community of inventors

Glenside, PA, United States of America

James G Kostelc