Nps Pharmaceuticals, Inc.

James G Busby

Thomas M Stormann

James E Garrett

Lance G Hammerland

Rachel T Simin

Laura L Storjohann

The present invention features G-protein fusion receptors and chimeric GABAreceptors (GABARs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from a CaR, an mGluR, and/or a GABAreceptor fused directly or through a linker to a guanine nucleotide-binding protein (G-protein). Chimeric GABARs comprise at least one of a GABAR extracellular domain, a GABAR transmembrane domain, or a GABAR intracellular domain and one or more domains from a mGluR subtype 8 (mGluR8) and/or a CaR.

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Simi Valley, CA, United States of America

James G Busby