Yale University

Other

James Frank Klemic

Mark A Reed

Tarek M Fahmy

Eric D Stern

Aleksandar Vacic

Mark T Reed

Michael Phillip Snyder

Rameez Saleh

Abigail Lubow

Mark Meras

Frederick J Sigworth

Kathryn G Klemic

The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

Nanoelectronic-enzyme linked immunosorbent assay system and method

The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (L) of the semiconductor material of which the semiconductor layer is formed.

CMOS-compatible silicon nano-wire sensors with biochemical and cellular interfaces

The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.

Protein chips for high throughput screening of protein activity

A security system includes within a single module in combination an arming component, a motion sensing component and a notifier component. The arming component creating an output signal received by the motion sensor component, which in turn generates an alarm signal upon the motion sensor being moved. The alarm signal activates a notifier component to broadcast notification of unauthorized movement of the system. A MEMS motion sensor and a trigger optimally serve as the basis for the motion sensing component.

Security system incorporating a single modular unit motion sensor

The present invention relates to ionic electrodes, particularly microelectrodes and electrode arrays, and also relates to fabrication methods for such electrodes. In particular, the present invention relates to planar polymer electrodes for making patch clamp measurements of ionic currents through biological membranes, such as the plasma membranes of living cells. The electrodes of the present invention are useful for measuring individual and multisite cell membrane currents and voltages, as well as in high-throughput screening procedures.

Growing community of inventors

New Haven, CT, United States of America

James Frank Klemic