Baylor College of Medicine

Other

Texas Heart Institute

James F Martin

John M Leach

Todd Ryan Heallen

Yuka Morikawa

Robert K Hamilton

Tanner Monroe

John Edward Steck

John E Steck

Debra Reeves

John Leach

Embodiments of the disclosure encompass methods and compositions related to modulating the Hippo pathway to inhibit fibrosis and/or inflammation in a tissue and/or organ of an individual in need thereof. In specific embodiments, the disclosure concerns modulation of LATS1, LATS2, or both, such as providing to the individual an effective amount of one or more agents that increase the levels of LATS1, LATS2, or both in the individual. In specific cases, cardiac fibrosis is treated with effective levels of vector(s) comprising LATS1, LATS2, or both.

Hippo regulation of cardiac vascularity, fibrosis, and inflammation

The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.

Dominant active yap, a hippo effector, induces chromatin accessibility and cardiomyocyte renewal

Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed.

Hippo and dystrophin complex signaling in cardiomyocyte renewal

Embodiments of the disclosure include methods and compositions related to treating or reducing the severity or delaying the onset of one or more cardiac conditions in a mammal. In particular embodiments, the compositions concern Park2 and its use for a cardiac medical condition. In specific cases, effective amounts of Park2 polynucleotide(s) and/or Park2 polypeptide(s) are provided to an individual in need thereof, including for heart failure, for example. The administration may be locally to the heart, for example.

Hippo pathway deficiency reverses systolic heart failure post-infarction

Loop crib

The present invention is directed to methods and compositions that provide therapy for at least one medical condition that directly or indirectly affects cardiac muscle cells (also known as cardiomyocytes) in a mammalian individual, including humans, dogs, cats, horse pigs, and so forth. The medical condition may be of any kind, including a cardiac condition such as heart failure, cardiomyopathy, myocardial infarction, and so forth. The medical condition may have a cardiac condition as its primary symptom or cause or it may be a secondary symptom or cause. The individual may be male or female and may be of any age.

Fishing lure safety cover

Disposable food cutting utensil

Light watercraft rack

A photographic image is prepared for facsimile transmission by photocopying the photographic image onto a sheet of paper through a partially transparent screen. The screen may comprise a plurality of spaced dots on a sheet in which one of the sheet and dots are transparent and the other opaque to light transmission whereby the photocopy has reproduced on it the picture and the pattern of the dots with either the dots or the spaces between the dots forming the image of the picture.

Facsimile transmission of photographic images

A simple, unitary tool which facilitates placement of shimming tape in the finger holes of a bowling ball and additionally can be used to enlarge the finger holes of such bowling ball. The tool comprises an elongated member and a pair of arms connected to such member. The arms respectively have a portion parallel to and spaced from the elongated member, the dimensions between such portions being less than the diameter of a bowling ball finger hole. A tape shim is threadable over the elongated member and under the arms to be retained thereby. The elongated member, with a threaded tape shim may be inserted into a bowling ball finger hole, pressed against the wall of such finger hole to transfer such tape shim to such finger hole to shim the finger hole, and then removed, leaving such tape shim properly secured to such finger hole. Additionally, the elongated member may include an abrasive surface portion spaced from the pair of arms. The abrasive surface is adapted to be selectively utilized to enlarge a bowling ball finger hole.

Growing community of inventors

Pearland, TX, United States of America

James F Martin