Minnesota Mining and Manufacturing Company

Medafor, Inc.

James F Drake, Jr

G Phillip Rambosek

Robert L Nelson

Fred R Paul, Jr

Ann Gronda

A method of detecting a beta-lactam antibiotic in a liquid sample comprising the steps of: (a) forming a reaction medium by adding the sample to a predetermined amount of a dry reagent formulation comprising a D,D-carboxypeptidase, a substrate for said D,D-carboxypeptidase containing a carboxy-terminal D-alanine, and a reagent system which produces a color change in the presence of D-alanine; (b) incubating said reaction medium for a predetermined period; (c) adding a quenching material to terminate the reaction; (d) observing the color of the reaction medium. A kit for carrying out this method is also disclosed.

Method and kit for detecting antibiotics in a liquid sample

Ballistic projectiles for subsonic propulsion having a helically twisted body portion nad a tapered nose portion and having an apparent density of up to 5 g/cm.sup.3. The projectiles can be propelled through barrels having a complementary barrel without objectionable fouling.

Ballistic projectile

A solid dose ballistic projectile formed entirely of a cohesive mixture comprising biologically active material, in the form of grindable solid particles having an average diameter between about 7 and 25 micrometers, and biologically inert binder, and capable of withstanding the stresses imparted thereon when the projectile is propelled ballistically from a barrel and implanted in the flesh of a living animal.

Solid dose ballistic projectile

A medium for growing bacteria from an initial population to a final predetermined population where growth of the bacteria substantially subsides due to the lack of nutrient.

Growth limiting media

Ballistically implantable projectile adapted to carry biologically active materials into a living animal body and thereafter to provide sustained release of said biologically active material into said living animal body.

Growing community of inventors

Minneapolis, MN, United States of America

James F Drake, Jr