Lantheus Medical Imaging, Inc.

Bristol-myers Squibb Pharma Company

The Dupont Merck Pharmaceutical Company

Adenosine Therapeutics, LLC

Rilling, Allan

Boudreau, Luc

James F Castner

Heike S Radeke

Richard R Cesati

Thomas David Harris

Edward H Cheesman

Robert W Siegler

James Eric Anderson

Joel Lazewatsky

Dianne D Zdankiewicz

Ajit B Thakur

Marybeth Devine

Enrico Mongeau

Hsun-Wen Hsu

James E Anderson

Luc Boudreau

Allan Rilling

Richard J Looby

Bobby E Corry

Robert Wilburn Siegler

The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g.,F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent, including methods of imaging in a subject comprising administering a composition comprising imaging agentto a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

Methods and apparatus for synthesizing imaging agents, and intermediates thereof

The invention relates to products and methods that provide increased yields of certain radiopharmaceuticals.

Radiopharmaceutical synthesis methods

Radiopharmaceutical compositions, and related methods, useful for medical imaging are provided. The radiopharmaceutical compositions include one or more radiopharmaceutical compounds, together with a stabilizer comprising ascorbic acid, wherein the pH of said composition is within the range of about 3.5-5.5.

Stabilization of radiopharmaceutical compositions using ascorbic acid

A stable composition useful for myocardial perfusion imaging contains one or more 2-alkynyladenosine derivatives; and a solvent which is made up of water and hydroxypropyl-&#x3b2;-cyclodextrin.

Adenosine derivative formulations for medical imaging

Apparatus and methods for monitoring the presence of an analyte in a closed vial wherein a sample contained within the closed vial is conveyed to an analyzer. The analyzer determines a value of a spectral property dependent on analyte concentration at a position within a headspace formed above the sample within the vial. An indicator is used to compare the measured value of the spectral property with a predetermined limit criteria to determine the presence or absence of the analyte. Vials wherein the presence of the analyte is detected are indicated as product vials whereas vials wherein the absence of the analyte is detected are indicated as rejected vials. The rejected vials are conveyed by a transferrer to a rejected vial station. A first portion of the product vials are conveyed by a sampler to a sample collection station. A second portion of the product vials are conveyed to a labeler.

Apparatus and methods for on-line monitoring of fluorinated material in headspace of vial

Apparatus and method for producing a radiopharmaceutical formulation utilize a radiation-shielding container for receiving a vial having the non-radioactive components necessary to form a radiopharmaceutical formulation therein. A mixture of such non-radioactive components and a radioactive liquid added thereto is both heated and cooled using a thermoelectric element. The container comprises a hollow outer shielding member formed from a radiation shielding material and a vial holder formed from a highly heat conductive material received therewithin. The vial holder includes a skirt portion that defines a socket. The socket is sized to receive in an intimate heat transmissive relationship a mounting projection that is itself connected in thermally conductive contact with the thermoelectric element. Using the thermoelectric heating and cooling element, heat is both applied to and removed from the radioactive liquid and the non-radioactive components within the vial while the vial is held within the vial holder within the radiation shielding container, thereby to produce a radiopharmaceutical formulation within the vial.

Apparatus and method for the preparation of a radiopharmaceutical

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Groton, MA, United States of America

James F Castner