Carnegie Mellon University

Other

University of Pittsburgh

World Heart Corporation

Mississippi State University

Nimbus, Incorporated

The United States of America As Represented by the Administrator of the

Vascor, Inc.

Antakamatics, Inc.

Antaki, James

Miles, Scott

Ludlow, Jed

James F Antaki

Gregory W Burgreen

Bradley Evan Paden

Alberto Gandini

William J Federspiel

Brian Joseph Frankowski

Nelson J Groom

John Andrew Holmes

Byron Wang Chuan

Joie N Marhefka

William Richard Wagner

Michael Richard Ricci

David Brian Paden

Mark B Friedman

David M Brienza

Kenneth C Butler

Josiah E Verkaik

Jed C Ludlow

Douglas C Thomas

Jingchun Wu

Mel Siegel

Shaun T Snyder

Sanna Gaspard

Sang-Ho Ye

Shalv Madhani

Todd M Przybycien

Richard Garrett Jeffries

John Robert Boston

Christian Andres Bermudez

Seongjin Choi

Scott D Miles

Marlin S Heilman

Joel S Greenberger

Christopher David Capone

Richard Andrew Sofranko

James A Magovern

Steve Andrew Kolenik

Edward Karl Prem

Don B Olsen

Greg A Johnson

James W Long

Gill Brent Bearnson

Paul E Allaire

Chen Chen

Carl Michael Parisi

Harvey S Borovetz

Daniel Richard Moore

Pratap S Khanwilkar

Matthew R Frushell

Brad E Paden

Michael Baloh

David C Borzelleca

Ruey C Dempsey

Greg Burgreen

Molly Blank

Ralph Scott Hebbert

Zhongjun Wu

Thomas David Will

Dave B Paden

Philip Schauer

Devin V Amin

Robert F Labadie

Juha-Pekka Mattila

Eliseo Salas

The present invention provides microfluidic pScreen™ devices for quantifying the concentration of DNA fragments in a liquid sample by using magnetic-responsive silica micro-beads and nonmagnetic-responsive silica micro-beads. The devices of the present invention allow for rapid, simple and inexpensive quantification of DNA fragment concentration in a sample. The devices do not require complex instrumentation and can be performed in less than three minutes. Moreover, they are compatible with complex samples including, without limitation, unpurified PCR amplification products, and thus can be expected to seamlessly integrate into various common molecular biology techniques and workflows.

Devices and methods for detection and quantification of immunological proteins, pathogenic and microbial agents and cells

An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle with a plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.

Extracorporeal ambulatory assist lung

A blood pump includes a housing having an inlet. A rotor disposed in the housing and configured to rotate substantially about the axis to pump blood from the inlet to the outlet. A stator is disposed within the housing and configured to drive rotation of the rotor about the axis. A bearing mechanism for supporting the rotor inside the housing includes a magnetic bearing configured to magnetically support the rotor inside the housing in a radial direction from the axis. The bearing mechanism includes a sliding bearing configured to physically support the rotor inside the housing in an axial direction along the axis of the housing and allow rotation of the rotor substantially about the axis, the sliding bearing comprising at least one point of contact where the rotor is configured to physically contact a trunnion affixed to the housing.

Blood-immersed bearing system for a blood pump

Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the patient and collects the optical reflectance data. The controller processes the data to determine whether there exists a pressure ulcer and, if there is one, its depth. The tip may also include a pressure sensor for sensing the pressure at which the tip is applied to the patient's skin.

Medical device for diagnosing pressure ulcers

A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers may extend generally perpendicular to the direction of bulk flow of blood through the housing.

Extracorporeal ambulator assist lung

An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle within the fiber bundle compartment. A plurality of hollow gas permeable fibers of the fiber bundle extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.

A magnetically-levitated blood pump with an optimization method that enables miniaturization and supercritical operation. The blood pump includes an optimized annular blood gap that increases blood flow and also provides a reduction in bearing stiffness among the permanent magnet bearings. Sensors are configured and placed optimally to provide space savings for the motor and magnet sections of the blood pump. Rotor mass is increased by providing permanent magnet placement deep within the rotor enabled by a draw rod configuration.

Magnetically-levitated blood pump with optimization method enabling miniaturization

A palpation device for palpation of tissues for characterization (e.g., qualification and/or quantification) of subcutaneous structures is provided. The palpation device includes a frame formed from a substantially rigid material and comprising an opening; a tonometric lens extending through the opening of the frame; and a radiation source. The lens is configured to at least partially impinge a tissue of interest to identify an object embedded therein. The lens includes a body having a reflective coating on an outer surface thereof. The radiation source is positioned to illuminate the reflective coating such that a topography of the coating can be observed. The body includes a body material that is as stiff or stiffer than the tissue of interest and less stiff than the embedded object to be characterized. A system including the palpation device and an image device for obtaining an image through the lens is also provided.

Device and method for palpation of tissues for characterization and mechanical differentiation of subcutaneous structures

The present invention provides a method and microfluidic immunoassay pScreen&#x2122; device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD, CDcells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.

The present invention provides methods and devices for attenuating sound emanating from a harmonica when played while practicing or performing by a player. The methods and devices include a sound blocking and reflecting means and, optionally, a sound absorbing means.

Methods and devices for muting a harmonica

A system for altering the pitch produced by a reed of a reeded instrument. The system comprises a reed having a first portion structured to be coupled to the instrument and a second portion generally free to vibrate and a magnet adjustably disposed adjacent the reed. The reed comprises a magnetic material.

Pitch altering mechanism for reeded instrument

The invention provides an apparatus and method for notating music for a harmonica. The apparatus incorporates a vertical staff in which vertical lines or tracks represent individual notes, the length of which represents duration of the note, and the horizontal location represents the physical location of the corresponding hole in a harmonica. The invention provides a rapid means of learning to play a harmonica and, for experienced players, provides a means for sight reading a new piece of music. The invention further provides ways of representing the dynamics of both pitch and loudness and a convenient way to manually transcribe musical selection for archival purposes.

Musical notation and method of teaching same

Growing community of inventors

Allison Park, PA, United States of America

James F Antaki