Astrazeneca Ab

James Empfield

Abdelmalik Slassi

Methvin Benjamin Isaac

Fupeng Ma

Ian Egle

Joshua Clayton

James Jeffrey Folmer

Scott Throner

Bradford C Van Wagenen

Rebecca Urbanek

Gary Steelman

Radhakrishnan Ukkiramapandian

Sally Walsh

Joseph Cacciola

Angela M Hunter

Stefan Berg

Eifion D Phillips

Sven Hellberg

James Woods

Ratan Bhat

Michael Thaddeus Klimas

Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators 842

Compounds of Formula (I) wherein Rand Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same. 

Oxadiazole derivatives and their use as metabotropic glutamate receptor potentiators&#x2014;842

Compounds of formula I: wherein R, R, R, R, R, R, R, R, Rand n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.

Metabotropic glutamate-receptor-potentiating isoindolones

Compounds in accord with Formula I: wherein R, R, Rand Rare as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

Metabotropic glutamate receptor isoxazole ligands and their use as potentiators&#x2014;286

The present invention is directed to compounds of formula I: wherein R, R, R, R, R, R, R, R, Rand n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Isoindolone compounds and their use as metabotropic glutamate receptor potentiators

Metabotropic glutamate receptor isoxazole ligands and their use as potentiators

Substituted isoindolones and their use as metabotropic glutamate receptor potentiators

Metabotropic glutamate receptor oxadiazole ligands and their use as potentiators 841

Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286

Compounds of formula I: wherein A and Rare as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

4-substituted imidazoles

The present invention relates to new compounds of formula (I) wherein Y, P, R, R, R, n, m are defined as in claim, a process for their preparation and new intermediates used therein, pharmaceutical composition containing said therapeutically active compounds and to the use of said active compounds in therapy, especially in the prevention and/or treatment of dementia related disease, Alzheimer's Disease and conditions associated with glycogen synthase kinase-3 

Compounds for the treatment of dementia related diseases

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Wilmington, DE, United States of America

James Empfield