The Secretary of State for Defence

The Secretary of State of Defence

James Edward Eyles

Ethel Diane Williamson

Richard William Titball

Sophie Jane Smither

Mitali Sarkar-Tyson

Michelle Nelson

Stephen John Elvin

Timothy Philip Atkins

Gareth David Healey

Julie Miller

Helen Claire Flick-Smith

Nicola Jane Walker

Emma Louise Waters

Leslie William Baillie

Leslie William Jones Baillie

An immunogenic agent which comprises a killed strain of, or a combination of components thereof which combination produces a protective immune response in an animal to whom it is administered, and which comprises at least two members selected from the group consisting of (i) a lipopolysaccharide of, (ii) a capsular polysaccharide ofand (iii) a protein ofor an immunogenic variant thereof or an immunogenic fragment of either of these, or a nucleic acid which expresses said protein, immunogenic variant or immunogenic fragment thereof in a host animal; for use in the prevention or treatment of infection byand/or

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Spore coat-associated proteins from members ofgenera, and in particular spore-coat associated protein N (CotN), have utilization as adjuvants in vaccine formulations. The vaccine formulations most likely contain a virulence factor of bacterial origin, which in the case ofgenera is the protective antigen.

Vaccine formulation

Growing community of inventors

Salisbury, United Kingdom

James Edward Eyles