Millennium Pharmaceuticals Limited

Other

University of Washington

Curagen Corporation

Bayer Healthcare Aktiengesellschaft

Kai Pharmaceuticals, Inc.

James E Tomlinson

James N Topper

Keith Earl Robison

Chi Kin Domingos Ng

Daniel R Storm

Ruey-Bing Yang

Beth Hacker

Laszlo G Komuves

Richard August Shimkets

Pamela B Conley

Catherine Burgess

Kimberly Spytek

Matthew E Hart

Sarah Walter

William Grosse

Ramesh Kekuda

Gregory Bell

Ruey-Bin Yang

Edward Szekeres, Jr

The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

Identification of a family of secreted proteins in vascular endothelium

The invention relates to novel human adenylyl cyclase nucleic acid and amino acid sequences. Also provided are vectors, host cells, recombinant methods for making and using the novel molecules and methods for identifying compounds which bind to the adenylyl cyclase proteins.

Method for identifying candidate compounds that bind to a human type IX adenylyl cyclase polypeptides

A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described.

Cloning and characterization of a human adenylyl cyclase

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Proteins and nucleic acids encoding same

A DNA sequence encoding a human type V adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described. This adenylyl cyclase is expressed in heart and brain tissue.

Human type V adenylyl cyclase

A DNA sequence encoding a human type V adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described. This adenylyl cyclase is expressed at increased levels in heart and brain tissue, relative to other tissues.

Polynucleotides encoding a type V adenylyl cyclase

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Burlingame, CA, United States of America

James E Tomlinson