Other

Vankel Technology Group

James E Swon

Henry Z Hofer

Amy C Little

Pradeepkumar P Sanghvi

Arnold H Beckett

Charles C Collins

Glen W Hill

In a preferred embodiment, there is an electronic comparator that monitors and exhibits on one or more video displays current information measured and monitored as to physical attributes relating to a revolvably rotating linearly-extending stirring shaft of which a distal end carries stirring blades positioned within media supported within a vessel stably mounted relative to a stably mounted drive mechanism and the stirring shaft, and a visual display video that during stirring displays visually the measured and monitored current degree of wobble of the stirring shaft, magnitude of vibrations of the stirring shaft, current degree of verticality of the stirring shaft, current temperature of media being stirred by the stirring shaft, current rate of revolutions per unit of time of the stirring shaft, a printing mechanism that prints current measured and monitored physical attributes onto a substrate, a computer interface structure and mechanism thereof adapted to convey measured and monitored physical attributes to one or more computer units and/or video monitors and/or printers thereof, and mounting structure for establishing and maintaining stable mounting and ascertained relative predetermined and established positioning to one-another of the stirring shaft's rotary drive structure and mechanism thereof, the stirring shaft, the vessel and the monitoring and measuring mechanism and structure thereof, during agitation of media by the blades on the distal end of the stirring shaft.

Stirring shaft monitoring comparator

For specialized use to secure reliable standardized complete distribution or solution of aggregate mixed into a liquid diluent, a vessel having an interior hemispherical concave bottom having extending upwardly centrally from the concave bottom an arcuate conical member having upright concavely-shaped circumscribing sides. The vessel is taken in conjunction with a stably mounted mixing structure having a downwardly-extending shaft and mixing blades thereof. The shaft on a lower portion thereof supports balanced mixing blades extending radially outwardly from the mixing shaft. The mixing blades are positioned to be substantially spaced below a predetermined liquid level of liquid diluent containing a dissolvable or suspendable aggregate and to be substantially spaced above an upper end of the centrally upwardly arcuate conical member. The blades when positioned and when the mixing structure is set to revolvably the blade at a predetermined result-intensive rpm, results in homogeneously distributed aggregate in liquid contained diluent.

Device maximizing dispersion of aggregate in liquid diluent

In a transdermal cell, a matter volume-adjustment male device includes the lower opening end of the through-space structure having inner wall female threads mateable with first male threads of a screwable matter volume-adjustment male member alternately adjustable upwardly and downwardly between opposite upper and lower female threads-termination points. The screwable matter volume-adjustment member has opposite first upper and lower male threads-termination points, and the inner wall female threads are further concurrently mateable with a bottom closure member having second male threads having opposite second upper and lower male threads-termination points. There is a first annular sealing ring sealably mounted in an annular groove around the screwable volume-adjustment male member between the first upper and lower threads-termination points positioned between the inner wall female threads and the first male threads, and there being a second annular sealing ring sealably mounted the second male threads at a location below the second upper termination point.

Transdermal cell test matter volume-adjustment device

In a preferred embodiment, a vessel-mouth annulus that precisely fits the inside-diameter of the upper mouth-opening to a water-containable tablet-dissolution stirring vessel, the vessel-mouth annulus being rigidly mounted on an anchoring structure rigidly attached to a paddle-shaft stirring device with one or more of the anchoring arm and/or the paddle-shaft stirring device being mounted in a predetermined fixed position on a base support structure such that a center of the dissolution vessel is centered in exact alignment with a predetermined fixed-position of a downwardly-extending lineally-extending stirrer-paddle shaft on which at-least one stirrer paddle is mounted on a lower end thereof for stirring liquid contained in the dissolution vessel during its operational use, and dissolution vessel support structure positioned to support the dissolution vessel in a state of alignment when the dissolution vessel is pressed upwardly against the aligning guide and holding means in a state of being aligned against inside diameter surfaces of the dissolution vessel. Additionally, rigidly and immovably a part of or mounted on at-least one of the vessel-mouth annulus and/or the anchoring structure and/or the paddle-shaft stirring device, there is included mounting structure for mounting a shaft-centering tester such that continuously or intermittently the revolvable shaft mounting the paddles, may be tested to verify continued exact centered positioning thereof relative to the centered mouth of the dissolution vessel. The tester-mounting structure is adapted to intermittently mount and dismount the the shaft-centering tester.

Tablet dissolution centering device

In a preferred embodiment of the invention, a transdermal patch holder is provided for making possible an ascertaining of drug release rate of a transdermal patch mountable thereon. The holder includes upper and lower spaced-apart aligned annular adapter disc structures forming aligned through-spaces. An upper surface of the lower disc structure has a centrally positioned stepped indentation forming a recess space seatable of the transdermal patch. The lower surface of the upper disc structure has a centrally positioned stepped downwardly-extending projection of slightly lesser cross-section than the cross-section of the recess space and is adapted to downwardly press upon an upper surface of a seated transdermal patch when the upper disc structure is intermittently in a latched state of being latched to the lower disc structure. A latching mechanism provided by outer circumscribing upright edges at each of opposite sides of each of the upper and lower disc structures has spaced-apart cut-aways forming a radially outwardly extending lateral projection therebetween, and lateral projections of the upper and lower disc structures aligned and having elastic annular bands intermittently mounted thereon securable of the upper and lower disc structures in face to face relationship. A transdermal patch is mountable and may be thereby held therebetween, with a handle-tab of the patch being seatable in and extendable through a laterally extending channel to laterally exterior space.

Transdermal patch holder

A combination for observing and recording required periods of time for dissolution and/or disintegration of pharmaceutical solid dosage forms such as tablets, including one or more, preferably two electronic video camera lense mechanisms positioned at different locations of surveillance of a plurality of different separate tablet-containing vessels each separately supporting different tablet(s) with liquid media, as observed by the camera lenses through window(s) of camera-lens support structure anchored onto a vessel (waterbath) containing the liquid media, the tablet-containing vessels being moved alternately upwardly and downwardly and/or revolvably, with a time recorder recording intermittently or continuously exact times of surveillance testing of tablets, and a monitor for playing-back on a single or preferably divided-screen recorded observations and recorded times associated therewith.

Video timing device for pharmaceutical tablet testing

A tester of resistance of separate batches of tablets to breakage including a revolvable cylinder revolvable around a central height axis that extends axially of the cylinder, cylindrical space formed therein being divided into separate spaces by dividing walls extending radially across a diameter of the inner cylindrical space and the dividing walls for each space having a radially extending concave surface along one radius and a convex surface along another radius such that in each of the separate spaces there is formed a scoop facilitating collecting and tossing groups of tablets as the cylindrical cylinder revolves, and the revolvable cylinder including an access opening-structure for separate insertion and removal of tablets from the separate spaces before and after tumbling. The revolvable cylinder includes as a part of its combination, a motor mechanism for intermittently revolving the cylinder, and a male-female connection for mounting and dismounting in association with the motor mechanism. Also, the access opening-structure is preferably in the nature of a lid having central male or female structure that mates with an opposite female or male structure extending axially of the cylinder, facilitating the securing of the lid. Also, the edge of the lid is preferably stepped, to partially fit within space of the cylinder when mounted thereon, improving the securing of the lid onto the cylinder.

Growing community of inventors

Brookside, NJ, United States of America

James E Swon